Literature DB >> 17085381

ERK1/2 MAP kinases in cell survival and apoptosis.

Zhimin Lu1, Shuichan Xu.   

Abstract

ERK1/2 is an important subfamily of mitogen-activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro-apoptotic functions.

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Year:  2006        PMID： 17085381     DOI： 10.1080/15216540600957438

Source DB:  PubMed          Journal:  IUBMB Life        ISSN： 1521-6543            Impact factor:   3.885


  231 in total

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