Literature DB >> 17085253

The alveolar-epithelial barrier: a target for potential therapy.

G R Scott Budinger1, Jacob I Sznajder.   

Abstract

During acute lung injury (ALI), the alveolar-capillary barrier is damaged, resulting in the accumulation of fluid and protein in the alveolar space characteristic of the acute respiratory distress syndrome (ARDS). Disordered epithelial repair may contribute to the development of fibrosis and worsen outcomes in patients who have lung injury. This article discusses novel emerging therapies based on these mechanisms that are designed to preserve the function and promote the repair of the alveolar epithelium in patients who have ALI/ARDS.

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Year:  2006        PMID: 17085253     DOI: 10.1016/j.ccm.2006.06.007

Source DB:  PubMed          Journal:  Clin Chest Med        ISSN: 0272-5231            Impact factor:   2.878


  21 in total

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2.  Oxidative stress-induced disruption of epithelial and endothelial tight junctions.

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3.  Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.

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Review 4.  The role of stretch-activated ion channels in acute respiratory distress syndrome: finally a new target?

Authors:  Andreas Schwingshackl
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2016-08-12       Impact factor: 5.464

Review 5.  Tidal volume in acute respiratory distress syndrome: how best to select it.

Authors:  Michele Umbrello; Antonella Marino; Davide Chiumello
Journal:  Ann Transl Med       Date:  2017-07

Review 6.  Gene therapy for ALI/ARDS.

Authors:  Xin Lin; David A Dean
Journal:  Crit Care Clin       Date:  2011-07       Impact factor: 3.598

Review 7.  Balancing the risks and benefits of oxygen therapy in critically III adults.

Authors:  G R Scott Budinger; Gökhan M Mutlu
Journal:  Chest       Date:  2013-04       Impact factor: 9.410

Review 8.  Ubiquitin-proteasome signaling in lung injury.

Authors:  Natalia D Magnani; Laura A Dada; Jacob I Sznajder
Journal:  Transl Res       Date:  2018-04-23       Impact factor: 7.012

9.  Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers.

Authors:  Parimal Sheth; Geetha Samak; J Andrew Shull; Ankur Seth; Radhakrishna Rao
Journal:  Biochem J       Date:  2009-06-12       Impact factor: 3.857

10.  Lysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrier disruption and lung injury.

Authors:  Donghong He; Yanlin Su; Peter V Usatyuk; Ernst Wm Spannhake; Paul Kogut; Julian Solway; Viswanathan Natarajan; Yutong Zhao
Journal:  J Biol Chem       Date:  2009-07-08       Impact factor: 5.157

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