BACKGROUND: Acute respiratory infections (ARI) are the leading cause of morbidity and mortality among children <5 years of age in developing countries. Human metapneumovirus (hMPV), a newly described respiratory pathogen, has been identified as an important cause of ARI in young children. OBJECTIVES: The objective was to describe the prevalence of hMPV in children who presented with ARI to a large referral hospital in Delhi, India and to genotype circulating strains on the basis of F gene nucleotide sequence analysis. STUDY DESIGN: We analyzed 97 samples from children <5 years of age with ARI seen at the All India Institute of Medical Sciences from June 2004 to March 2005. RT-PCR was performed for the N and F genes and partial F gene nucleotide sequences were used to characterize the viruses. RESULTS: hMPV was identified in 12% of children with ARI, including 13% of the children hospitalized with ARI. Most virus identification occurred in the winter. The Indian strains clustered in the A2 genetic sublineage. CONCLUSIONS: This report establishes hMPV as an important cause of ARI in children in India.
BACKGROUND:Acute respiratory infections (ARI) are the leading cause of morbidity and mortality among children <5 years of age in developing countries. Human metapneumovirus (hMPV), a newly described respiratory pathogen, has been identified as an important cause of ARI in young children. OBJECTIVES: The objective was to describe the prevalence of hMPV in children who presented with ARI to a large referral hospital in Delhi, India and to genotype circulating strains on the basis of F gene nucleotide sequence analysis. STUDY DESIGN: We analyzed 97 samples from children <5 years of age with ARI seen at the All India Institute of Medical Sciences from June 2004 to March 2005. RT-PCR was performed for the N and F genes and partial F gene nucleotide sequences were used to characterize the viruses. RESULTS:hMPV was identified in 12% of children with ARI, including 13% of the children hospitalized with ARI. Most virus identification occurred in the winter. The Indian strains clustered in the A2 genetic sublineage. CONCLUSIONS: This report establishes hMPV as an important cause of ARI in children in India.
Authors: Julie A Pavlin; Andrew C Hickey; Nancy Ulbrandt; Yee-Peng Chan; Timothy P Endy; Marina S Boukhvalova; Supamit Chunsuttiwat; Ananda Nisalak; Daniel H Libraty; Sharone Green; Alan L Rothman; Francis A Ennis; Richard Jarman; Robert V Gibbons; Christopher C Broder Journal: J Infect Dis Date: 2008-09-15 Impact factor: 5.226
Authors: Maria Mathisen; Tor A Strand; Biswa N Sharma; Ram K Chandyo; Palle Valentiner-Branth; Sudha Basnet; Ramesh K Adhikari; Dag Hvidsten; Prakash S Shrestha; Halvor Sommerfelt Journal: BMC Med Date: 2009-07-27 Impact factor: 8.775
Authors: Betty E Owor; Geoffrey N Masankwa; Lilian C Mwango; Regina W Njeru; Charles N Agoti; D James Nokes Journal: BMC Infect Dis Date: 2016-06-17 Impact factor: 3.090