| Literature DB >> 17084991 |
Xiaoping Gao1, Bogang Li, Hanwen Jiang, Fenglin Liu, Dayong Xu, Zhongrong Liu.
Abstract
The effects of Dioscorea opposita (huai shan yao, HSY) on dexamethasone-induced insulin resistance were investigated in vitro and in vivo. D. opposita extract reduced significantly the blood insulin and glucose levels in dexamethasone-induced diabetic rats. In vitro, HSY significantly enhanced insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Moreover, HSY increase the mRNA expression of GLUT4 glucose transporter in 3T3-L1 adipocytes. These data suggest that D. opposita has insulin sensitivity that is associated with the regulation of GLUT4 expression.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17084991 DOI： 10.1016/j.fitote.2006.09.015
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882