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Literature DB >> 17084709

Convergence between bone and energy homeostases: leptin regulation of bone mass.

Abstract

The observation that obesity protects from osteoporosis suggested that energy metabolism and bone mass could be regulated by the same hormones. Testing this hypothesis revealed that leptin regulates bone mass through a hypothalamic relay and using two neural mediators, the sympathetic tone and CART, both acting on one cell type the osteoblast. This review summarizes the genetic and molecular bases of this regulation and discusses its potential clinical implications.

Entities: Disease Gene

Mesh：

Substances：
Leptin

Year: 2006 PMID： 17084709 DOI： 10.1016/j.cmet.2006.10.008

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

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Cited

126 in total

1. Tissue-specific expression of Sprouty1 in mice protects against high-fat diet-induced fat accumulation, bone loss and metabolic dysfunction.

Authors: Sumithra Urs; Terry Henderson; Phuong Le; Clifford J Rosen; Lucy Liaw
Journal: Br J Nutr Date: 2011-12-06 Impact factor: 3.718

Review 2. Examining the link between bariatric surgery, bone loss, and osteoporosis: a review of bone density studies.

Authors: Lesley M Scibora; Sayeed Ikramuddin; Henry Buchwald; Moira A Petit
Journal: Obes Surg Date: 2012-04 Impact factor: 4.129

3. Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo.

Authors: Yu Shi; Vijay K Yadav; Nina Suda; X Sherry Liu; X Edward Guo; Martin G Myers; Gerard Karsenty
Journal: Proc Natl Acad Sci U S A Date: 2008-12-11 Impact factor: 11.205

4. Soy protein isolate inhibits high-fat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in male rats.

Authors: Jin-Ran Chen; Oxana P Lazarenko; Michael L Blackburn; Thomas M Badger; Martin J J Ronis
Journal: Endocrinology Date: 2014-12-09 Impact factor: 4.736

5. Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women.

Authors: R Saucedo; G Rico; G Vega; L Basurto; L Cordova; R Galvan; M Hernandez; E Puello; A Zarate
Journal: J Endocrinol Invest Date: 2014-12-06 Impact factor: 4.256

10. Significant association between body composition phenotypes and the osteocalcin genomic region in normative human population.

Authors: Michael Korostishevsky; Ida Malkin; Svetlana Trofimov; Yufang Pei; Hong-Wen Deng; Gregory Livshits
Journal: Bone Date: 2012-07-24 Impact factor: 4.398

Convergence between bone and energy homeostases: leptin regulation of bone mass.

1. Tissue-specific expression of Sprouty1 in mice protects against high-fat diet-induced fat accumulation, bone loss and metabolic dysfunction.

Review 2. Examining the link between bariatric surgery, bone loss, and osteoporosis: a review of bone density studies.

3. Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo.

4. Soy protein isolate inhibits high-fat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in male rats.

5. Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women.

6. Cocaine and amphetamine-regulated transcript may regulate bone remodeling as a circulating molecule.

7. Mechanisms mediating renal sympathetic activation to leptin in obesity.

8. Visceral fat is a negative predictor of bone density measures in obese adolescent girls.

Review 9. Muscle-bone and fat-bone interactions in regulating bone mass: do PTH and PTHrP play any role?

10. Significant association between body composition phenotypes and the osteocalcin genomic region in normative human population.