Literature DB >> 17084708

Discovering orphans' sweet secret: NR4A receptors and hepatic glucose production.

Mauricio Berriel Diaz1, Ulrike Lemke, Stephan Herzig.   

Abstract

Aberrant hepatic gluconeogenesis contributes importantly to hyperglycemia in type II diabetic patients. A study by Pei et al. (2006b) identifies NR4A orphan nuclear receptors as a novel branch of cAMP-dependent regulators of hepatic glucose production under healthy and diabetic conditions.

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Year:  2006        PMID: 17084708     DOI: 10.1016/j.cmet.2006.10.005

Source DB:  PubMed          Journal:  Cell Metab        ISSN: 1550-4131            Impact factor:   27.287


  6 in total

1.  The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of β-cell mass.

Authors:  Anne-Françoise Close; Nidheesh Dadheech; Bárbara Scoralick Villela; Claude Rouillard; Jean Buteau
Journal:  J Biol Chem       Date:  2019-01-29       Impact factor: 5.157

2.  Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish.

Authors:  Yang Xu; Juanjuan Tian; Qi Kang; Hang Yuan; Chengdong Liu; Zhehui Li; Jie Liu; Mingyu Li
Journal:  Front Endocrinol (Lausanne)       Date:  2022-04-25       Impact factor: 6.055

3.  In Silico Adoption of an Orphan Nuclear Receptor NR4A1.

Authors:  Harald Lanig; Felix Reisen; David Whitley; Gisbert Schneider; Lee Banting; Timothy Clark
Journal:  PLoS One       Date:  2015-08-13       Impact factor: 3.240

Review 4.  Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes.

Authors:  Chenyang Zhang; Bin Zhang; Xuelian Zhang; Guibo Sun; Xiaobo Sun
Journal:  Front Pharmacol       Date:  2020-11-27       Impact factor: 5.810

Review 5.  The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases.

Authors:  Lei Zhang; Qun Wang; Wen Liu; Fangyan Liu; Ailing Ji; Yanzhang Li
Journal:  J Diabetes Res       Date:  2018-06-14       Impact factor: 4.011

6.  NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β-cells for protection.

Authors:  Ze-Qing Pu; Dong Liu; Hanse Pablick Patherny Lobo Mouguegue; Cheng-Wen Jin; Esha Sadiq; Dan-Dan Qin; Tian-Fu Yu; Chen Zong; Ji-Cui Chen; Ru-Xing Zhao; Jing-Yu Lin; Jie Cheng; Xiao Yu; Xia Li; Yu-Chao Zhang; Yuan-Tao Liu; Qing-Bo Guan; Xiang-Dong Wang
Journal:  J Cell Mol Med       Date:  2020-10-30       Impact factor: 5.295

  6 in total

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