Literature DB >> 1708252

Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth.

K Matsumoto1, H Tajima, T Nakamura.   

Abstract

Hepatocyte growth factor (HGF) is a potent mitogen for adult rat hepatocytes in primary culture. HGF stimulates growth and DNA synthesis of normal human epidermal melanocytes in culture. The maximal stimulation of DNA synthesis by 4.0-fold occurred with 10 ng/ml HGF. This stimulatory effect was additive with both acidic and basic fibroblast growth factors, while it was inhibited by transforming growth factor-beta 1. Melanocytes expressed a single class of specific, high-affinity receptors for HGF with a Kd of 22 pM and approximately 120 receptors/cell. Thus, HGF is a potent mitogen for normal human epidermal melanocytes.

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Year:  1991        PMID： 1708252     DOI： 10.1016/0006-291x(91)90887-d

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  40 in total

Review 1.  Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis.

Authors:  Okkyung Rho; Dae Joon Kim; Karou Kiguchi; John Digiovanni
Journal:  Mol Carcinog       Date:  2010-07-20       Impact factor: 4.784

2.  UV-B radiation induces macrophage migration inhibitory factor-mediated melanogenesis through activation of protease-activated receptor-2 and stem cell factor in keratinocytes.

Authors:  Akiko Enomoto; Yoko Yoshihisa; Takako Yamakoshi; Mati Ur Rehman; Osamu Norisugi; Hiroshi Hara; Kenji Matsunaga; Teruhiko Makino; Jun Nishihira; Tadamichi Shimizu
Journal:  Am J Pathol       Date:  2011-02       Impact factor: 4.307

3.  Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R.

Authors:  Kerrington R Molhoek; Amber L Shada; Mark Smolkin; Sudhir Chowbina; Jason Papin; David L Brautigan; Craig L Slingluff
Journal:  Melanoma Res       Date:  2011-08       Impact factor: 3.599

4.  Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene.

Authors:  S Giordano; Z Zhen; E Medico; G Gaudino; F Galimi; P M Comoglio
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

5.  Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride.

Authors:  J J Maher
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

6.  Hepatocyte growth factor (HGF/SF) is expressed in human epithelial cells during embryonic development; studies by in situ hybridisation and northern blot analysis.

Authors:  Y Wang; C Selden; S Farnaud; D Calnan; H J Hodgson
Journal:  J Anat       Date:  1994-12       Impact factor: 2.610

7.  Effect of growth factors and prostaglandin E2 on restitution and proliferation of rabbit esophageal epithelial cells.

Authors:  P Jimenez; A Lanas; E Piazuelo; F Esteva
Journal:  Dig Dis Sci       Date:  1998-10       Impact factor: 3.199

8.  Hepatocyte growth factor/scatter factor expression in human mammary epithelium.

Authors:  Y Wang; A C Selden; N Morgan; G W Stamp; H J Hodgson
Journal:  Am J Pathol       Date:  1994-04       Impact factor: 4.307

9.  Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.

Authors:  W M Mars; R Zarnegar; G K Michalopoulos
Journal:  Am J Pathol       Date:  1993-09       Impact factor: 4.307

10.  Identification and characterization of "injurin," an inducer of expression of the gene for hepatocyte growth factor.

Authors:  K Matsumoto; H Tajima; M Hamanoue; S Kohno; T Kinoshita; T Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205
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