| Literature DB >> 17081970 |
Jetta K McGill1, M Flint Beal.
Abstract
The coactivator PGC-1alpha is a key regulator of mitochondrial biogenesis and respiration, mediating expression of several transcription factors required for these programs. Three new studies reveal that PGC-1alpha expression is downregulated in patients with Huntington's disease (HD) and in several animal models of this neurodegenerative disorder, implicating PGC-1alpha in HD pathogenesis and providing a connection between impaired energy metabolism and neurodegeneration.Entities:
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Year: 2006 PMID： 17081970 DOI： 10.1016/j.cell.2006.10.023
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582