Literature DB >> 17080998

Condensation of alpha-aroylketene dithioacetals and 2-hydroxyarylaldehydes results in facile synthesis of a combinatorial library of 3-aroylcoumarins.

H Surya Prakash Rao1, S Sivakumar.   

Abstract

A facile, convenient, efficient, and high yielding synthesis of a combinatorial library of 3-aroylcoumarins has been developed by the condensation of easily available alpha-aroylketene dithioacetals (AKDTAs) and 2-hydroxybenzaldehydes (salicylaldehydes)/2-hydroxy-1-naphthaldehyde in the presence of catalytic amount of piperidine in THF reflux. The condensation of ferrocene derived alpha-aroylketene dithioacetal and 2-hydroxybenzaldehyde furnished coumarin installed on a ferrocene platform.

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Year:  2006        PMID： 17080998     DOI： 10.1021/jo061372e

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  8 in total

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Journal:  Pharmaceuticals (Basel)       Date:  2022-05-31

Review 2.  Recent advances in the application of indoles in multicomponent reactions.

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Journal:  RSC Adv       Date:  2018-03-28       Impact factor: 4.036

3.  Knoevenagel reaction in [MMIm][MSO₄]: synthesis of coumarins.

Authors:  Pedro Verdía; Francisco Santamarta; Emilia Tojo
Journal:  Molecules       Date:  2011-05-27       Impact factor: 4.411

4.  Discovery of Coumarin as Microtubule Affinity-Regulating Kinase 4 Inhibitor That Sensitize Hepatocellular Carcinoma to Paclitaxel.

Authors:  Xianyan Shen; Xuesha Liu; Shunli Wan; Xin Fan; Huaiyu He; Rong Wei; Wenchen Pu; Yong Peng; Chun Wang
Journal:  Front Chem       Date:  2019-05-24       Impact factor: 5.221

5.  Metal-Free Vinyl C-H Sulfenylation/Alkyl Thiolation of Ketene Dithioacetals for the Synthesis of Polythiolated Alkenes.

Authors:  Leiling Deng; Yunyun Liu
Journal:  ACS Omega       Date:  2018-09-25

6.  Studies of Coumarin Derivatives for Constitutive Androstane Receptor (CAR) Activation.

Authors:  Shin-Hun Juang; Min-Tsang Hsieh; Pei-Ling Hsu; Ju-Ling Chen; Hui-Kang Liu; Fong-Pin Liang; Sheng-Chu Kuo; Chen-Yuan Chiu; Shing-Hwa Liu; Chen-Hsi Chou; Tian-Shung Wu; Hsin-Yi Hung
Journal:  Molecules       Date:  2020-12-31       Impact factor: 4.411

7.  Methyl 2-oxo-2H-chromene-3-carboxyl-ate.

Authors:  Aamer Saeed; Aalia Ibrar; Muhammad Arshad; Michael Bolte
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-26

8.  Aroylketene dithioacetal chemistry: facile synthesis of 4-aroyl-3-methylsulfanyl-2-tosylpyrroles from aroylketene dithioacetals and TosMIC.

Authors:  H Surya Prakash Rao; S Sivakumar
Journal:  Beilstein J Org Chem       Date:  2007-09-28       Impact factor: 2.883
  8 in total

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