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Literature DB >> 17079431

Specificity of the immune response to a modified group B meningococcal polysaccharide conjugate vaccine.

Samuel Moore¹, Esmé K Farley, Peter C Fusco, Francis Michon.

Abstract

Antibodies to a modified group B meningococcal polysaccharide vaccine were examined for antigenic and functional specificities. Bactericidal determinants were investigated by using immunoaffinity columns and competitive inhibition of bactericidal activity in an in vitro killing assay. We conclude that nearly all of the vaccine-induced bactericidal activity is specific for the native polysaccharide.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2006 PMID： 17079431 PMCID： PMC1797716 DOI： 10.1128/CVI.00216-06

Source DB: PubMed Journal: Clin Vaccine Immunol ISSN： 1556-679X

24 in total

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Authors: N E Rosenstein; B A Perkins; D S Stephens; T Popovic; J M Hughes
Journal: N Engl J Med Date: 2001-05-03 Impact factor: 91.245

2. Induction of meningococcal group B polysaccharide-specific IgG antibodies in mice by using an N-propionylated B polysaccharide-tetanus toxoid conjugate vaccine.

Authors: H J Jennings; R Roy; A Gamian
Journal: J Immunol Date: 1986-09-01 Impact factor: 5.422

3. Determinant specificities of the groups B and C polysaccharides of Neisseria meningitidis.

Authors: H J Jennings; R Roy; F Michon
Journal: J Immunol Date: 1985-04 Impact factor: 5.422

4. Bactericidal monoclonal antibodies that define unique meningococcal B polysaccharide epitopes that do not cross-react with human polysialic acid.

Authors: D M Granoff; A Bartoloni; S Ricci; E Gallo; D Rosa; N Ravenscroft; V Guarnieri; R C Seid; A Shan; W R Usinger; S Tan; Y E McHugh; G R Moe
Journal: J Immunol Date: 1998-05-15 Impact factor: 5.422

5. Immunologic response of man to group B meningococcal polysaccharide vaccines.

Authors: F A Wyle; M S Artenstein; B L Brandt; E C Tramont; D L Kasper; P L Altieri; S L Berman; J P Lowenthal
Journal: J Infect Dis Date: 1972-11 Impact factor: 5.226

6. Molecular analysis of anti-N-propionyl Neisseria meningitidis group B polysaccharide monoclonal antibodies.

Authors: Gregory R Moe; Apurva Dave; Dan M Granoff
Journal: Mol Immunol Date: 2005-09-02 Impact factor: 4.407

7. Measurement of antibodies to meningococcal group B polysaccharide: low avidity binding and equilibrium binding constants.

Authors: R E Mandrell; W D Zollinger
Journal: J Immunol Date: 1982-11 Impact factor: 5.422

Specificity of the immune response to a modified group B meningococcal polysaccharide conjugate vaccine.

Review 1. Meningococcal disease.

2. Induction of meningococcal group B polysaccharide-specific IgG antibodies in mice by using an N-propionylated B polysaccharide-tetanus toxoid conjugate vaccine.

3. Determinant specificities of the groups B and C polysaccharides of Neisseria meningitidis.

4. Bactericidal monoclonal antibodies that define unique meningococcal B polysaccharide epitopes that do not cross-react with human polysialic acid.

5. Immunologic response of man to group B meningococcal polysaccharide vaccines.

6. Molecular analysis of anti-N-propionyl Neisseria meningitidis group B polysaccharide monoclonal antibodies.

7. Measurement of antibodies to meningococcal group B polysaccharide: low avidity binding and equilibrium binding constants.

8. Complex of meningococcal group B polysaccharide and type 2 outer membrane protein immunogenic in man.

Review 9. Polysialic acid: three-dimensional structure, biosynthesis and function.

10. N-propionylated group B meningococcal polysaccharide mimics a unique epitope on group B Neisseria meningitidis.

Review 1. Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development.