| Literature DB >> 17079095 |
Amy E Hulme1, Hal P Bogerd, Bryan R Cullen, John V Moran.
Abstract
The non-LTR retrotransposon LINE-1 (L1) comprises approximately 17% of the human genome, and the L1-encoded proteins can function in trans to mediate the retrotransposition of non-autonomous retrotransposons (i.e., Alu and probably SVA elements) and cellular mRNAs to generate processed pseudogenes. Here, we have examined the effect of APOBEC3G and APOBEC3F, cytidine deaminases that inhibit Vif-deficient HIV-1 replication, on Alu retrotransposition and other L1-mediated retrotransposition processes. We demonstrate that APOBEC3G selectively inhibits Alu retrotransposition in an ORF1p-independent manner. An active cytidine deaminase site is not required for the inhibition of Alu retrotransposition and the resultant integration events lack G to A or C to T hypermutation. These data demonstrate a differential restriction of L1 and Alu retrotransposition by APOBEC3G, and suggest that the Alu ribonucleoprotein complex may be targeted by APOBEC3G.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17079095 PMCID： PMC2917221 DOI： 10.1016/j.gene.2006.08.032
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688