| Literature DB >> 17078995 |
Salvatore Grasso1, Laura Siracusa, Carmela Spatafora, Marcella Renis, Corrado Tringali.
Abstract
The olive oil phenol hydroxytyrosol (3), as well its metabolite homovanillic alcohol (4), were subjected to chemoselective lipase-catalysed acylations, affording with good yield 10 derivatives (5-14) bearing C(2), C(3), C(4), C(10) and C(18) acyl chains at C-1. Hydroxytyrosol (3) and its lipophilic derivatives showed very good DPPH. radical scavenging activity. Compounds 3, 4 and their lipophilic analogues 5-14 were subjected to the atypical Comet test on whole blood cells: 3 and its analogues 5 and 6, with little hydrophobic character (logP<or=1.20), showed a good protective effect against H(2)O(2) induced oxidative DNA damage. The homovanillic alcohol 4 and its analogues 10-14 resulted scarcely effective both as radical scavengers and antioxidant agents.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17078995 DOI： 10.1016/j.bioorg.2006.09.003
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275