Literature DB >> 1707871

Deadenylation and turnover of interferon-beta mRNA.

K Peppel1, C Baglioni.   

Abstract

The pathway of degradation of human interferon-beta (IFN-beta) mRNA was examined in murine C127 cells that carry an expression vector for this mRNA. The IFN-beta mRNA decayed with a half-life of approximately 45 min in actinomycin D-treated cells and became gradually shorter. This mRNA was superinduced in cycloheximide-treated cells, but it also became gradually shorter. However, apparently full-length species of IFN-beta mRNA accumulated after prolonged incubation with cycloheximide. The shortened IFN-beta mRNA species were partially deadenylated and less stable than full-length species. These findings suggest that at least two nuclease activities are involved in degrading IFN-beta mRNA; one deadenylates this mRNA and decays in cycloheximide-treated cells, while the other apparently breaks down deadenylated mRNA.

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Year:  1991        PMID： 1707871

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  13 in total

1.  The poly(A) tail inhibits the assembly of a 3'-to-5' exonuclease in an in vitro RNA stability system.

Authors:  L P Ford; P S Bagga; J Wilusz
Journal:  Mol Cell Biol       Date:  1997-01       Impact factor: 4.272

2.  Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38.

Authors:  M Lasa; M Brook; J Saklatvala; A R Clark
Journal:  Mol Cell Biol       Date:  2001-02       Impact factor: 4.272

Review 3.  mRNA stability in mammalian cells.

Authors:  J Ross
Journal:  Microbiol Rev       Date:  1995-09

4.  The deadenylation conferred by the 3' untranslated region of a developmentally controlled mRNA in Xenopus embryos is switched to polyadenylation by deletion of a short sequence element.

Authors:  P Bouvet; F Omilli; Y Arlot-Bonnemains; V Legagneux; C Roghi; T Bassez; H B Osborne
Journal:  Mol Cell Biol       Date:  1994-03       Impact factor: 4.272

5.  AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A).

Authors:  C A Lagnado; C Y Brown; G J Goodall
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

6.  Rapid mRNA degradation mediated by the c-fos 3' AU-rich element and that mediated by the granulocyte-macrophage colony-stimulating factor 3' AU-rich element occur through similar polysome-associated mechanisms.

Authors:  E Winstall; M Gamache; V Raymond
Journal:  Mol Cell Biol       Date:  1995-07       Impact factor: 4.272

7.  Pumilio response and AU-rich elements drive rapid decay of Pnrc2-regulated cyclic gene transcripts.

Authors:  Kiel T Tietz; Thomas L Gallagher; Monica C Mannings; Zachary T Morrow; Nicolas L Derr; Sharon L Amacher
Journal:  Dev Biol       Date:  2020-04-01       Impact factor: 3.582

8.  Interferon-gamma inhibits interleukin-8 production by human polymorphonuclear leucocytes.

Authors:  M A Cassatella; I Guasparri; M Ceska; F Bazzoni; F Rossi
Journal:  Immunology       Date:  1993-02       Impact factor: 7.397

9.  Repression of beta interferon gene expression in virus-infected cells is correlated with a poly(A) tail elongation.

Authors:  E Dehlin; A von Gabain; G Alm; R Dingelmaier; O Resnekov
Journal:  Mol Cell Biol       Date:  1996-02       Impact factor: 4.272

10.  Binding of a protein to an AU-rich domain of tumour necrosis factor alpha mRNA as a 35 kDa complex and its regulation in primary rat astrocytes.

Authors:  Y U Kim; H G Rus; S N Fisher; P M Pitha; M L Shin
Journal:  Biochem J       Date:  1996-06-01       Impact factor: 3.857
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