Literature DB >> 17078705

Total synthesis of (+/-)-morphine.

Kenji Uchida1, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama.   

Abstract

[Structure: see text] The morphinan skeleton was effectively synthesized by an intramolecular Mannich-type reaction. Further transformation led to total synthesis of morphine.

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Year:  2006        PMID： 17078705     DOI： 10.1021/ol062112m

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Opportunities in metabolic engineering to facilitate scalable alkaloid production.

Authors:  Effendi Leonard; Weerawat Runguphan; Sarah O'Connor; Kristala Jones Prather
Journal:  Nat Chem Biol       Date:  2009-05       Impact factor: 15.040

2.  Synthesis of 2-substituted 7-hydroxybenzofuran-4-carboxylates via addition of silyl enol ethers to o-benzoquinone esters.

Authors:  Michael E Jung; Felix Perez
Journal:  Org Lett       Date:  2009-05-21       Impact factor: 6.005

3.  Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance.

Authors:  Paul T Bremer; Kim D Janda
Journal:  J Med Chem       Date:  2012-11-15       Impact factor: 7.446

4.  A Cascade Strategy Enables a Total Synthesis of (±)-Morphine.

Authors:  Shuyu Chu; Niels Münster; Tudor Balan; Martin D Smith
Journal:  Angew Chem Int Ed Engl       Date:  2016-10-13       Impact factor: 15.336

5.  Programmed serial stereochemical relay and its application in the synthesis of morphinans.

Authors:  Kun Ho Kenny Park; Rui Chen; David Y-K Chen
Journal:  Chem Sci       Date:  2017-08-30       Impact factor: 9.825

6.  Asymmetric synthesis of (-)-naltrexone.

Authors:  Sun Dongbang; Blaine Pedersen; Jonathan A Ellman
Journal:  Chem Sci       Date:  2018-10-23       Impact factor: 9.825

7.  Intramolecular carbonickelation of alkenes.

Authors:  Rudy Lhermet; Muriel Durandetti; Jacques Maddaluno
Journal:  Beilstein J Org Chem       Date:  2013-04-12       Impact factor: 2.883
  7 in total

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