Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Drug evaluation: ISIS-301012, an antisense oligonucleotide for the treatment of hypercholesterolemia.

Literature DB >> 17078389

Drug evaluation: ISIS-301012, an antisense oligonucleotide for the treatment of hypercholesterolemia.

Abstract

ISIS-301012 is an antisense oligonucleotide inhibitor of apolipoprotein B-100, which is being developed by Isis Pharmaceuticals Inc for the potential treatment of hypercholesterolemia. A subcutaneous injectable formulation is currently undergoing phase 11 clinical trials, while phase I trials are underway with an oral formulation of the drug.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2006 PMID： 17078389

Source DB: PubMed Journal: Curr Opin Mol Ther ISSN： 1464-8431

Keyword Cloud
Cited

7 in total

1. Does inhibition of apolipoprotein B synthesis produce foie gras?

Authors: Kenneth R Feingold
Journal: J Lipid Res Date: 2009-12-30 Impact factor: 5.922

2. Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice.

Authors: Adam E Mullick; Wuxia Fu; Mark J Graham; Richard G Lee; Donna Witchell; Thomas A Bell; Charles P Whipple; Rosanne M Crooke
Journal: J Lipid Res Date: 2011-02-22 Impact factor: 5.922

3. Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins.

Authors: Hua Huang; Fang Sun; David M Owen; Weiping Li; Yan Chen; Michael Gale; Jin Ye
Journal: Proc Natl Acad Sci U S A Date: 2007-03-21 Impact factor: 11.205

Drug evaluation: ISIS-301012, an antisense oligonucleotide for the treatment of hypercholesterolemia.

1. Does inhibition of apolipoprotein B synthesis produce foie gras?

2. Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice.

3. Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins.

Review 4. Hepatitis C virus: a new class of virus associated with particles derived from very low-density lipoproteins.

Review 5. Targeting host factors: a novel rationale for the management of hepatitis C virus.

Review 6. New treatments for chronic hepatitis C.

Review 7. Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.