Literature DB >> 17078387

Progress towards the clinical application of helper-dependent adenoviral vectors for liver and lung gene therapy.

Nicola Brunetti-Pierri1, Philip Ng.   

Abstract

This review focuses on recent developments in helper-dependent adenoviral technology and preclinical studies for helper-dependent adenovirus-mediated liver- and lung-directed gene therapy. Studies highlighting the tremendous potential of these vectors are reviewed, together with some important obstacles that will need to be addressed before clinical utility.

Entities:  

Mesh：

Year:  2006        PMID： 17078387

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  7 in total

Review 1.  Gene delivery to the airway.

Authors:  Nicholas W Keiser; John F Engelhardt
Journal:  Curr Protoc Hum Genet       Date:  2013-07

2.  Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primates.

Authors:  Nicola Brunetti-Pierri; Gary E Stapleton; Mark Law; John Breinholt; Donna J Palmer; Yu Zuo; Nathan C Grove; Milton J Finegold; Karen Rice; Arthur L Beaudet; Charles E Mullins; Philip Ng
Journal:  Mol Ther       Date:  2008-12-02       Impact factor: 11.454

Review 3.  Progress and prospects: prospects of repeated pulmonary administration of viral vectors.

Authors:  P L Sinn; E R Burnight; P B McCray
Journal:  Gene Ther       Date:  2009-07-30       Impact factor: 5.250

4.  Calcium gluconate in phosphate buffered saline increases gene delivery with adenovirus type 5.

Authors:  Marko T Ahonen; Iulia Diaconu; Sari Pesonen; Anna Kanerva; Marc Baumann; Suvi T Parviainen; Brad Spiller; Vincenzo Cerullo; Akseli Hemminki
Journal:  PLoS One       Date:  2010-09-30       Impact factor: 3.240

Review 5.  Challenges and Prospects for Helper-Dependent Adenoviral Vector-Mediated Gene Therapy.

Authors:  Pasquale Piccolo; Nicola Brunetti-Pierri
Journal:  Biomedicines       Date:  2014-04-02

Review 6.  Genetic Delivery and Gene Therapy in Pulmonary Hypertension.

Authors:  Nabham Rai; Mazen Shihan; Werner Seeger; Ralph T Schermuly; Tatyana Novoyatleva
Journal:  Int J Mol Sci       Date:  2021-01-25       Impact factor: 5.923

7.  Helper-dependent adenoviral vectors for liver-directed gene therapy of primary hyperoxaluria type 1.

Authors:  R Castello; R Borzone; S D'Aria; P Annunziata; P Piccolo; N Brunetti-Pierri
Journal:  Gene Ther       Date:  2015-12-24       Impact factor: 5.250
  7 in total

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