Jennifer Y F Lau1, Thalia C Eley. 1. Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health,15K North Drive, Room 211, Bethesda, MD 20892-2670, USA. lauj@mail.nih.gov
Abstract
BACKGROUND: Depression rises markedly in adolescence, a time when increased and new genetic influences have been reported. AIMS: To examine'new'and'stable' genetic and environmental factors on depressive symptoms in adolescence and young adulthood. METHOD: A questionnaire survey investigated a sample of twin and sibling pairs at three time points over an approximately 3-year period. Over 1800 twin and sibling pairs reported depressive symptoms at the three time points. Data were analysed using multivariate genetic models. RESULTS: Depressive symptoms at all time points were moderately heritable with substantial non-shared environmental contributions. Wave 1 genetic factors accounted for continuity of symptoms at waves 2 and 3. 'New'genetic effects at wave 2 also influenced wave 3 symptoms. New non-shared environmental influences emerged at each time point. CONCLUSIONS: New genetic and environmental influences may explain age-related increases in depression across development.
BACKGROUND: Depression rises markedly in adolescence, a time when increased and new genetic influences have been reported. AIMS: To examine'new'and'stable' genetic and environmental factors on depressive symptoms in adolescence and young adulthood. METHOD: A questionnaire survey investigated a sample of twin and sibling pairs at three time points over an approximately 3-year period. Over 1800 twin and sibling pairs reported depressive symptoms at the three time points. Data were analysed using multivariate genetic models. RESULTS: Depressive symptoms at all time points were moderately heritable with substantial non-shared environmental contributions. Wave 1 genetic factors accounted for continuity of symptoms at waves 2 and 3. 'New'genetic effects at wave 2 also influenced wave 3 symptoms. New non-shared environmental influences emerged at each time point. CONCLUSIONS: New genetic and environmental influences may explain age-related increases in depression across development.
Authors: Donald W Black; William H Coryell; Raymond R Crowe; Brett McCormick; Martha C Shaw; Jeff Allen Journal: J Clin Psychiatry Date: 2014-03 Impact factor: 4.384
Authors: Mollie N Moore; Rachel H Salk; Carol A Van Hulle; Lyn Y Abramson; Janet S Hyde; Kathryn Lemery-Chalfant; H Hill Goldsmith Journal: Clin Psychol Sci Date: 2013-07-01
Authors: Jennifer Y F Lau; David Goldman; Beata Buzas; Colin Hodgkinson; Ellen Leibenluft; Eric Nelson; Lindsey Sankin; Daniel S Pine; Monique Ernst Journal: Neuroimage Date: 2009-11-17 Impact factor: 6.556