| Literature DB >> 17076690 |
Patrícia Pereira1, Paulo Alexandre de Oliveira, Patrícia Ardenghi, Liane Rotta, João Antonio Pêgas Henriques, Jaqueline Nascimento Picada.
Abstract
The aim of the present study was to investigate the effect of intraperitoneal administration of caffeic acid (0.5, 1, 2, 4 or 8 mg/kg) on elevated plus-maze and open field tasks in rats and its possible neuroprotection/neurotoxicity using the comet assay. Caffeic acid at 1 mg/kg increased the number of entries and the time spent in the open arms on plus-maze, suggesting an anxiolytic-like effect when used in lower doses without affecting locomotion and exploration on the open field. Furthermore, a protective effect against hydrogen peroxide-induced oxidative damage on brain tissue was observed through the treatment with caffeic acid at 1 and 8 mg/kg. However, in the highest dose, caffeic acid induced DNA damage in brain tissue.Entities:
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Year: 2006 PMID： 17076690 DOI： 10.1111/j.1742-7843.2006.pto_533.x
Source DB: PubMed Journal: Basic Clin Pharmacol Toxicol ISSN： 1742-7835 Impact factor: 4.080