Literature DB >> 1707648

Detection of blood group A and H-related antigens in normal and neoplastic bladder epithelium: a comparative study using monoclonal antibodies with defined fine specificities.

S J Thorpe1, P Abel.   

Abstract

Three monoclonal anti-blood group H and four monoclonal anti-blood group A antibodies directed at the blood group antigens on Type 1 or Type 2 backbone structures were evaluated as immunohistochemical reagents by indirect immunofluorescence of normal and neoplastic bladder epithelia. The results were compared with fluorescence using polyclonal rabbit anti-A or H sera or Ulex europaeus lectin. The monoclonal antibodies gave less intense or more restricted immunofluorescence than the conventional reagents but showed considerable variation in the extent of their reactivities with urothelial samples from different individuals. In some cases they failed to give immunofluorescence with tissue samples known to contain the immunodominant blood group structures they recognize. In addition, hitherto unsuspected heterogeneity was revealed in the expression of the Type 2-based blood group H and A-structures in the endothelia of neighbouring small blood vessels.

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Year:  1991        PMID： 1707648      PMCID： PMC2002302     

Source DB:  PubMed          Journal:  Int J Exp Pathol        ISSN： 0959-9673            Impact factor:   1.925


  12 in total

1.  Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens.

Authors:  T Feizi
Journal:  Nature       Date:  1985 Mar 7-13       Impact factor: 49.962

Review 2.  ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution.

Authors:  H Clausen; S Hakomori
Journal:  Vox Sang       Date:  1989       Impact factor: 2.144

3.  Fading of immunofluorescence during microscopy: a study of the phenomenon and its remedy.

Authors:  G D Johnson; R S Davidson; K C McNamee; G Russell; D Goodwin; E J Holborow
Journal:  J Immunol Methods       Date:  1982-12-17       Impact factor: 2.303

4.  Blood group ABO and Lewis antigen expression during neoplastic progression of human urothelium. Immunohistochemical study of type 1 chain structures.

Authors:  T F Orntoft; M J Nielsen; H Wolf; S Olsen; H Clausen; S Hakomori; E Dabelsteen
Journal:  Cancer       Date:  1987-12-01       Impact factor: 6.860

5.  Blood group antigen expression in frozen sections of presenting bladder cancer: 3-year prospective follow-up of prognostic value.

Authors:  P D Abel; S J Thorpe; G Williams
Journal:  Br J Urol       Date:  1989-02

6.  Expression of blood group antigens in urinary tract tumours: prospective fluorescence study using cryostat sections of fresh frozen tissues.

Authors:  S J Thorpe; P Abel; D Henderson; N Jones; T Feizi
Journal:  J Clin Pathol       Date:  1986-11       Impact factor: 3.411

7.  Activity of the human blood group ABO, Se, H, Le, and X gene-encoded glycosyltransferases in normal and malignant bladder urothelium.

Authors:  T F Orntoft; H Wolf; W M Watkins
Journal:  Cancer Res       Date:  1988-08-01       Impact factor: 12.701

8.  Marker of peripheral blood granulocytes and monocytes of man recognized by two monoclonal antibodies VEP8 and VEP9 involves the trisaccharide 3-fucosyl-N-acetyllactosamine.

Authors:  H C Gooi; S J Thorpe; E F Hounsell; H Rumpold; D Kraft; O Förster; T Feizi
Journal:  Eur J Immunol       Date:  1983-04       Impact factor: 5.532

9.  Monoclonal antibody (EGR/G49) reactive with the epidermal growth factor receptor of A431 cells recognizes the blood group ALeb and ALey structures.

Authors:  H C Gooi; J K Picard; E F Hounsell; M Gregoriou; A R Rees; T Feizi
Journal:  Mol Immunol       Date:  1985-06       Impact factor: 4.407

10.  Blood group antigens in the normal and neoplastic bladder epithelium.

Authors:  S J Thorpe; P Abel; G Slavin; T Feizi
Journal:  J Clin Pathol       Date:  1983-08       Impact factor: 3.411
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