Literature DB >> 17075603

Clinical implications of neuroendocrine differentiation in prostate cancer.

E C Nelson1, A J Cambio, J C Yang, J-H Ok, P N Lara, C P Evans.   

Abstract

The cellular signaling pathways of the prostate play a central role in the induction, maintenance, and progression of prostate cancer (CaP). Neuroendocrine (NE) cells demonstrate attributes that suggest they are an integral part of these signaling cascades. We summarize what is known regarding NE cells in CaP focusing on NE cellular transdifferentiation. This significant event in CaP progression appears to be accelerated by androgen deprivation (AD) treatment. We examine biochemical pathways that may impact NE differentiation in a chronological manner focusing on AD therapy (ADT) as a central event in inducing androgen-independent CaP. Our analysis is limited to the common adenocarcinoma pattern of CaP and excludes small-cell and carcinoid prostatic variants. In conclusion, we speculate on the future of treatment and research in this area.

Entities:  

Mesh：

Year:  2006        PMID： 17075603     DOI： 10.1038/sj.pcan.4500922

Source DB:  PubMed          Journal:  Prostate Cancer Prostatic Dis        ISSN： 1365-7852            Impact factor:   5.554


  32 in total

1.  Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer.

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2.  Ionizing radiation induces prostate cancer neuroendocrine differentiation through interplay of CREB and ATF2: implications for disease progression.

Authors:  Xuehong Deng; Han Liu; Jiaoti Huang; Liang Cheng; Evan T Keller; Sarah J Parsons; Chang-Deng Hu
Journal:  Cancer Res       Date:  2008-12-01       Impact factor: 12.701

3.  Ionizing radiation induces neuroendocrine differentiation of prostate cancer cells in vitro, in vivo and in prostate cancer patients.

Authors:  Xuehong Deng; Bennett D Elzey; Jean M Poulson; Wallace B Morrison; Song-Chu Ko; Noah M Hahn; Timothy L Ratliff; Chang-Deng Hu
Journal:  Am J Cancer Res       Date:  2011-08-18       Impact factor: 6.166

4.  Ki67 staining index and neuroendocrine differentiation aggravate adverse prognostic parameters in prostate cancer and are characterized by negligible inter-observer variability.

Authors:  Sven Gunia; Knut Albrecht; Stefan Koch; Thomas Herrmann; Thorsten Ecke; Volker Loy; Jörg Linke; Michael Siegsmund; Matthias May
Journal:  World J Urol       Date:  2008-04-05       Impact factor: 4.226

5.  Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2.

Authors:  Zuzana Pernicová; Eva Slabáková; Gvantsa Kharaishvili; Jan Bouchal; Milan Král; Zuzana Kunická; Miroslav Machala; Alois Kozubík; Karel Souček
Journal:  Neoplasia       Date:  2011-06       Impact factor: 5.715

6.  Reduction of two histone marks, H3k9me3 and H3k27me3 by epidrug induces neuroendocrine differentiation in prostate cancer.

Authors:  Eunsohl Lee; Jingcheng Wang; Younghun Jung; Frank C Cackowski; Russell S Taichman
Journal:  J Cell Biochem       Date:  2018-01-09       Impact factor: 4.429

7.  CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes.

Authors:  Younghun Jung; Frank C Cackowski; Kenji Yumoto; Ann M Decker; Jingcheng Wang; Jin Koo Kim; Eunsohl Lee; Yugang Wang; Jae-Seung Chung; Amy M Gursky; Paul H Krebsbach; Kenneth J Pienta; Todd M Morgan; Russell S Taichman
Journal:  Cancer Res       Date:  2018-02-05       Impact factor: 12.701

8.  Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation.

Authors:  Janeen H Trembley; Gretchen M Unger; Omar Cespedes Gomez; J Abedin; Vicci L Korman; Rachel I Vogel; Gloria Niehans; Betsy T Kren; Khalil Ahmed
Journal:  Mol Cell Pharmacol       Date:  2014

Review 9.  Redox-mediated and ionizing-radiation-induced inflammatory mediators in prostate cancer development and treatment.

Authors:  Lu Miao; Aaron K Holley; Yanming Zhao; William H St Clair; Daret K St Clair
Journal:  Antioxid Redox Signal       Date:  2014-01-22       Impact factor: 8.401

10.  Oct4A is expressed by a subpopulation of prostate neuroendocrine cells.

Authors:  Paula Sotomayor; Alejandro Godoy; Gary J Smith; Wendy J Huss
Journal:  Prostate       Date:  2009-03-01       Impact factor: 4.104
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