Literature DB >> 17074844

Fully virulent Bacillus anthracis does not require the immunodominant protein BclA for pathogenesis.

J Bozue1, C K Cote, K L Moody, S L Welkos.   

Abstract

The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores; however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant (bclA) of the fully virulent Ames strain. This derivative retained full virulence in several small-animal models of infection despite the bclA deletion.

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Year:  2006        PMID： 17074844      PMCID： PMC1828395          DOI： 10.1128/IAI.01202-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  30 in total

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5.  The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores.

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Review 6.  Anthrax.

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  22 in total

1.  A novel spore protein, ExsM, regulates formation of the exosporium in Bacillus cereus and Bacillus anthracis and affects spore size and shape.

Authors:  Monica M Fazzini; Raymond Schuch; Vincent A Fischetti
Journal:  J Bacteriol       Date:  2010-06-11       Impact factor: 3.490

2.  Localization and assembly of proteins comprising the outer structures of the Bacillus anthracis spore.

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3.  Role of purine biosynthesis in Bacillus anthracis pathogenesis and virulence.

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4.  Activation of the classical complement pathway by Bacillus anthracis is the primary mechanism for spore phagocytosis and involves the spore surface protein BclA.

Authors:  Chunfang Gu; Sarah A Jenkins; Qiong Xue; Yi Xu
Journal:  J Immunol       Date:  2012-03-21       Impact factor: 5.422

Review 5.  The Exosporium Layer of Bacterial Spores: a Connection to the Environment and the Infected Host.

Authors:  George C Stewart
Journal:  Microbiol Mol Biol Rev       Date:  2015-12       Impact factor: 11.056

6.  Cryo-EM analysis of the organization of BclA and BxpB in the Bacillus anthracis exosporium.

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Journal:  J Struct Biol       Date:  2014-03-06       Impact factor: 2.867

7.  Roles of the Bacillus anthracis spore protein ExsK in exosporium maturation and germination.

Authors:  Kari M Severson; Michael Mallozzi; Joel Bozue; Susan L Welkos; Christopher K Cote; Katherine L Knight; Adam Driks
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8.  In vivo demonstration and quantification of intracellular Bacillus anthracis in lung epithelial cells.

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9.  The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytes.

Authors:  Claudia R Oliva; Melissa K Swiecki; Corinne E Griguer; Mark W Lisanby; Daniel C Bullard; Charles L Turnbough; John F Kearney
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10.  Assembly of the BclB glycoprotein into the exosporium and evidence for its role in the formation of the exosporium 'cap' structure in Bacillus anthracis.

Authors:  Brian M Thompson; Bryce C Hoelscher; Adam Driks; George C Stewart
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