Literature DB >> 17074482

Novel poly(ADP-ribose) polymerase-1 inhibitors.

Derek Dunn1, Jean Husten, Mark A Ator, Sankar Chatterjee.   

Abstract

Synthesis and activity of a series of 4-thiazol-yl substituted analogs of novel pyrrolocarbazole 1 as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been disclosed.

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Year:  2006        PMID： 17074482     DOI： 10.1016/j.bmcl.2006.10.010

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  The 1.8 Å cholix toxin crystal structure in complex with NAD+ and evidence for a new kinetic model.

Authors:  Robert J Fieldhouse; René Jørgensen; Miguel R Lugo; A Rod Merrill
Journal:  J Biol Chem       Date:  2012-04-25       Impact factor: 5.157

2.  Developing novel approaches to improve binding energy estimation and virtual screening: a PARP case study.

Authors:  Fedor N Novikov; Viktor S Stroylov; Oleg V Stroganov; Val Kulkov; Ghermes G Chilov
Journal:  J Mol Model       Date:  2009-04-16       Impact factor: 1.810

3.  Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.

Authors:  Daniel Spinks; Leah S Torrie; Stephen Thompson; Justin R Harrison; Julie A Frearson; Kevin D Read; Alan H Fairlamb; Paul G Wyatt; Ian H Gilbert
Journal:  ChemMedChem       Date:  2011-12-08       Impact factor: 3.466
  3 in total

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