Literature DB >> 17074379

Extensive cross-reactive neutralizing antibody response in Indian patients with limited genetic diversity of HIV-1.

Samir K Lakhashe1, Smita S Kulkarni, Madhuri R Thakar, Manisha V Ghate, Ramesh S Paranjape.   

Abstract

Genome sequence analysis of HIV-1 subtype C viruses from India shows monophyletic lineage and relatively limited genetic diversity. To understand its immunological implication, cross-reactivity of neutralizing antibody response was investigated. In primary screening, neutralizing antibody response to single heterologous primary HIV-1 subtype C isolate was assessed in plasma samples from 235 HIV-1 infected, anti-retroviral treatment naive individuals from Pune, India. Plasma samples that showed > or =90% neutralization and two randomly selected plasma samples that showed 50-60% neutralization were tested against a panel of primary HIV-1 subtype C isolates obtained from epidemiologically unlinked individuals from India. The neutralizing antibody response showed extensive cross-neutralization, suggesting presence of shared neutralization determinants among circulating HIV-1 subtype C viruses in India.

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Year:  2006        PMID： 17074379     DOI： 10.1016/j.virol.2006.09.019

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  7 in total

1.  Neutralization potential of the plasma of HIV-1 infected Indian patients in the context of anti-V3 antibody content and antiretroviral therapy. [corrected].

Authors:  Alok Kumar Choudhary; Raiees Andrabi; Somi Sankaran Prakash; Rajesh Kumar; Shubhasree Dutta Choudhury; Naveet Wig; Ashutosh Biswas; Anjali Hazarika; Kalpana Luthra
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2.  Nasal delivery of PLG microparticle encapsulated defensin peptides adjuvanted gp41 antigen confers strong and long-lasting immunoprotective response against HIV-1.

Authors:  Teena Mohan; D Mitra; D N Rao
Journal:  Immunol Res       Date:  2014-01       Impact factor: 2.829

Review 3.  HIV infection in India: epidemiology, molecular epidemiology and pathogenesis.

Authors:  Samir Lakhashe; Madhuri Thakar; Sheela Godbole; Srikanth Tripathy; Ramesh Paranjape
Journal:  J Biosci       Date:  2008-11       Impact factor: 1.826

4.  Quantitation of HLA proteins incorporated by human immunodeficiency virus type 1 and assessment of neutralizing activity of anti-HLA antibodies.

Authors:  Samir K Lakhashe; Madhuri R Thakar; K E Bharucha; Ramesh S Paranjape
Journal:  J Virol       Date:  2007-10-17       Impact factor: 5.103

5.  Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India.

Authors:  Smita S Kulkarni; Alan Lapedes; Haili Tang; S Gnanakaran; Marcus G Daniels; Ming Zhang; Tanmoy Bhattacharya; Ming Li; Victoria R Polonis; Francine E McCutchan; Lynn Morris; Dennis Ellenberger; Salvatore T Butera; Robert C Bollinger; Bette T Korber; Ramesh S Paranjape; David C Montefiori
Journal:  Virology       Date:  2009-01-23       Impact factor: 3.616

6.  Identification of CD4-Binding Site Dependent Plasma Neutralizing Antibodies in an HIV-1 Infected Indian Individual.

Authors:  Lubina Khan; Muzamil Ashraf Makhdoomi; Sanjeev Kumar; Ambili Nair; Raiees Andrabi; Brenda E Clark; Kate Auyeung; Jayanta Bhattacharya; Madhu Vajpayee; Naveet Wig; Ralph Pantophlet; Kalpana Luthra
Journal:  PLoS One       Date:  2015-05-11       Impact factor: 3.240

7.  Neutralization of tier-2 viruses and epitope profiling of plasma antibodies from human immunodeficiency virus type 1 infected donors from India.

Authors:  Raiees Andrabi; Manju Bala; Rajesh Kumar; Naveet Wig; Anjali Hazarika; Kalpana Luthra
Journal:  PLoS One       Date:  2012-08-31       Impact factor: 3.240
  7 in total

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