| Literature DB >> 17074307 |
Hideyuki Kobayashi1, Hiroki Yokoo, Toshihiko Yanagita, Shinya Satoh, Bela Kis, Maria Deli, Masami Niwa, Akihiko Wada.
Abstract
Water homeostasis in the brain is essential for brain function. We have studied how aquaporin (AQP) 1 expression in GP8 immortalized rat brain microvascular endothelial cells is regulated by glucocorticoid. AQP1 protein level was raised by dexamethasone treatment in a time- and concentration-dependent manner. The up-regulation of AQP1 protein by dexamethasone was associated with an increase of AQP1 mRNA level, with no change in the degradation rate of AQP1 mRNA. AQP1 was concentrated in detergent-insoluble fractions in the cells treated with or without dexamethasone, suggesting that function/trafficking of AQP1 may be regulated via the interaction with lipid rafts. Since glucocorticoid therapy has well known beneficial effects in the treatment of brain edema, the induction of AQP1 by dexamethasone raises a possibility that AQP1 plays a role in ameliorating brain edema.Entities:
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Year: 2006 PMID： 17074307 DOI： 10.1016/j.brainres.2006.09.066
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252