Literature DB >> 17073765

The impact of pregnane X receptor activation on liver fibrosis.

M C Wright1.   

Abstract

The PXR (pregnane X receptor) is a nuclear receptor transcription factor that is activated by a range of endobiotics and xenobiotics. The activated PXR modulates the transcription of genes in hepatocytes (the main functional cell of the liver) associated with endobiotic and xenobiotic uptake, metabolism and excretion. However, activation of the PXR also inhibits a deleterious response of the liver to chronic damage--that of fibrosis. The antifibrogenic mode of action is mediated through changes in the expression of genes in hepatic stellate cells and liver macrophages (Kupffers). These results suggest an additional function for the PXR.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17073765     DOI： 10.1042/BST0341119

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  11 in total

1.  SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts.

Authors:  Barbara Renga; Andrea Mencarelli; Marco Migliorati; Sabrina Cipriani; Claudio D'Amore; Eleonora Distrutti; Stefano Fiorucci
Journal:  Inflamm Res       Date:  2011-01-29       Impact factor: 4.575

Review 2.  Genetic epidemiology of primary sclerosing cholangitis.

Authors:  Tom-H Karlsen; Erik Schrumpf; Kirsten-Muri Boberg
Journal:  World J Gastroenterol       Date:  2007-11-07       Impact factor: 5.742

Review 3.  Genetics of primary sclerosing cholangitis and pathophysiological implications.

Authors:  Xiaojun Jiang; Tom H Karlsen
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2017-03-15       Impact factor: 46.802

Review 4.  Nuclear receptors and nonalcoholic fatty liver disease.

Authors:  Matthew C Cave; Heather B Clair; Josiah E Hardesty; K Cameron Falkner; Wenke Feng; Barbara J Clark; Jennifer Sidey; Hongxue Shi; Bashar A Aqel; Craig J McClain; Russell A Prough
Journal:  Biochim Biophys Acta       Date:  2016-03-04

Review 5.  Molecular mechanisms involved in NAFLD progression.

Authors:  Mariano Malaguarnera; Michelino Di Rosa; Ferdinando Nicoletti; Lucia Malaguarnera
Journal:  J Mol Med (Berl)       Date:  2009-04-08       Impact factor: 4.599

Review 6.  Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.

Authors:  Arunima Biswas; Sridhar Mani; Matthew R Redinbo; Matthew D Krasowski; Hao Li; Sean Ekins
Journal:  Pharm Res       Date:  2009-05-05       Impact factor: 4.200

Review 7.  Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases.

Authors:  Sundhar Mohandas; Balasubramaniyan Vairappan
Journal:  World J Hepatol       Date:  2017-11-18

Review 8.  The Nuclear Receptor PXR in Chronic Liver Disease.

Authors:  Katia Sayaf; Ilaria Zanotto; Francesco Paolo Russo; Daniela Gabbia; Sara De Martin
Journal:  Cells       Date:  2021-12-27       Impact factor: 6.600

9.  The PXR is a drug target for chronic inflammatory liver disease.

Authors:  Karen Wallace; David E Cowie; Dimitrios K Konstantinou; Stephen J Hill; Torunn E Tjelle; Andrew Axon; Matthew Koruth; Steven A White; Harald Carlsen; Derek A Mann; Matthew C Wright
Journal:  J Steroid Biochem Mol Biol       Date:  2010-04-21       Impact factor: 4.292

10.  Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics.

Authors:  Carylyn J Marek; Karen Wallace; Elaine Durward; Matthew Koruth; Val Leel; Lucy J Leiper; Matthew C Wright
Journal:  Comp Hepatol       Date:  2009-05-11
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.