| Literature DB >> 17073710 |
R Griffith1, M N Brown, A McCluskey, L K Ashman.
Abstract
Small molecule protein kinase inhibitors show great promise as anti-cancer agents, however, de novo and acquired resistance present problems. These are reviewed and illustrated using the receptor tyrosine kinase, KIT, as an example. Emerging solutions are presented, such as targeting active kinase conformations.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17073710 DOI： 10.2174/138955706778560184
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862