Literature DB >> 17073707

Intracellular amyloid beta-protein and its associated molecules in the pathogenesis of Alzheimer's disease.

Yasumasa Ohyagi1, Takeshi Tabira.   

Abstract

Amyloid beta-protein (Abeta) plays a pivotal role in Alzheimer's disease (AD). Therapeutic strategies inhibiting Abeta aggregation and promoting extracellular Abeta removal are currently advocated. Here, we review recent literature on intracellular Abeta, especially intranuclear Abeta, and its associated molecules. We also discuss alternative therapeutic strategies to inhibit intracellular Abeta-related pathogenesis.

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Year:  2006        PMID： 17073707     DOI： 10.2174/138955706778560175

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  10 in total

1.  Effect of hypothalamic proline-rich peptide (PRP-1) on neuronal and bone marrow cell apoptosis.

Authors:  Armen A Galoyan; Josef Krieglstein; Susanne Klumpp; Kristina E Danielian; Karine A Galoian; Wolfram Kremers; Kristina B Bezirganyan; Tigran K Davtyan
Journal:  Neurochem Res       Date:  2007-06-05       Impact factor: 3.996

2.  Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis.

Authors:  Jason A Bailey; Bryan Maloney; Yuan-Wen Ge; Debomoy K Lahiri
Journal:  Gene       Date:  2011-06-25       Impact factor: 3.688

3.  The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif.

Authors:  Bryan Maloney; Debomoy K Lahiri
Journal:  Gene       Date:  2011-06-15       Impact factor: 3.688

4.  The Small Molecule GAL-201 Efficiently Detoxifies Soluble Amyloid β Oligomers: New Approach towards Oral Disease-Modifying Treatment of Alzheimer's Disease.

Authors:  Hermann Russ; Michele Mazzanti; Chris Parsons; Katrin Riemann; Alexander Gebauer; Gerhard Rammes
Journal:  Int J Mol Sci       Date:  2022-05-21       Impact factor: 6.208

Review 5.  MicroRNA implications across neurodevelopment and neuropathology.

Authors:  Sabata Martino; Ilaria di Girolamo; Antonio Orlacchio; Alessandro Datti; Aldo Orlacchio
Journal:  J Biomed Biotechnol       Date:  2009-10-13

6.  Evaluation of BACE1 Silencing in Cellular Models.

Authors:  Malgorzata Sierant; Katarzyna Kubiak; Julia Kazmierczak-Baranska; Masaki Warashina; Tomoko Kuwabara; Barbara Nawrot
Journal:  Int J Alzheimers Dis       Date:  2009-07-14

7.  Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation.

Authors:  Xifei Yang; Ying Yang; Geng Li; Jianzhi Wang; Edward S Yang
Journal:  J Mol Neurosci       Date:  2008-01-05       Impact factor: 3.444

8.  β-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A.

Authors:  Kesava Rao Venkata Kurapati; Thangavel Samikkannu; Venkata Subba Rao Atluri; Elena Kaftanovskaya; Adriana Yndart; Madhavan P N Nair
Journal:  PLoS One       Date:  2014-11-21       Impact factor: 3.240

Review 9.  siRNA Therapeutics: Future Promise for Neurodegenerative Diseases.

Authors:  Atefeh Amiri; George Barreto; Thozhukat Sathyapalan; Amirhossein Sahebkar
Journal:  Curr Neuropharmacol       Date:  2021       Impact factor: 7.708

10.  Ashwagandha (Withania somnifera) reverses β-amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive disorders (HAND).

Authors:  Kesava Rao Venkata Kurapati; Venkata Subba Rao Atluri; Thangavel Samikkannu; Madhavan P N Nair
Journal:  PLoS One       Date:  2013-10-16       Impact factor: 3.240
  10 in total

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