Z Zamir1, A Mahmud, J Feely. 1. Dept of Pharmacology and Therapeutics, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8.
Abstract
BACKGROUND: Invasive studies in middle-aged patients suggest an acute adverse haemodynamic effect of smoking. AIMS: To study acute changes in blood pressure (BP), cardiac output, peripheral resistance and aortic compliance following cigarette smoking in healthy young subjects. METHODS: Using a non-invasive photoplethysmographic technique we compared the effects of smoking one cigarette with sham smoking in 12 healthy volunteers (22-25 years). Data was analysed using JMP version 5.0. RESULTS: In contrast to sham smoking there was a prompt increase in blood pressure with a maximum effect at 15 min (123 +/- 7/75 +/- 5 to 143 +/- 6/86 +/- 6 mmHg, mean +/- SEM, p < 0.01) which is attributed to a rise in cardiac output (p < 0.05) rather than changes in peripheral vascular resistance. There was also a significant (p < 0.05) increase in heart rate and a reduction in aortic compliance. CONCLUSION: These results suggest that healthor young age do not protect from the adverse effects of smoking.
BACKGROUND: Invasive studies in middle-aged patients suggest an acute adverse haemodynamic effect of smoking. AIMS: To study acute changes in blood pressure (BP), cardiac output, peripheral resistance and aortic compliance following cigarette smoking in healthy young subjects. METHODS: Using a non-invasive photoplethysmographic technique we compared the effects of smoking one cigarette with sham smoking in 12 healthy volunteers (22-25 years). Data was analysed using JMP version 5.0. RESULTS: In contrast to sham smoking there was a prompt increase in blood pressure with a maximum effect at 15 min (123 +/- 7/75 +/- 5 to 143 +/- 6/86 +/- 6 mmHg, mean +/- SEM, p < 0.01) which is attributed to a rise in cardiac output (p < 0.05) rather than changes in peripheral vascular resistance. There was also a significant (p < 0.05) increase in heart rate and a reduction in aortic compliance. CONCLUSION: These results suggest that healthor young age do not protect from the adverse effects of smoking.
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