AIM: To determine the prevalence of celiac disease in a group of volunteer blood donors at a blood bank in the city of Curitiba, Brazil through detection of the serum marker immunoglobulin A (IgA) antitransglutaminase antibody. METHODS: Blood samples collected from 2086 healthy subjects at the Paraná State Center for Hematology and Hemotherapy in Curitiba were submitted to ELISA testing for the IgA antitransglutaminase antibody. Positive samples received IgA antiendomysium antibody test through indirect immunofluorescence using human umbilical cord as substrate. Subsequently, patients who were positive on both tests underwent small bowel (distal duodenum) biopsy. RESULTS: Six subjects, four males and two females, tested positive for the two serum markers. Five of the six were submitted to intestinal biopsy (one declined the procedure). Biopsy results revealed changes in the distal duodenum mucosa (three classified as Marsh IIIb lesions and two as Marsh II lesions). Most donors diagnosed having celiac disease presented multiple symptoms (gastrointestinal tract complaints). One donor reported having a family history of celiac disease (in a niece). CONCLUSION: Among apparently healthy blood donors, the prevalence of biopsy-confirmed celiac disease was approximately 1:417, similar to that seen in European countries.
AIM: To determine the prevalence of celiac disease in a group of volunteer blood donors at a blood bank in the city of Curitiba, Brazil through detection of the serum marker immunoglobulin A (IgA) antitransglutaminase antibody. METHODS: Blood samples collected from 2086 healthy subjects at the Paraná State Center for Hematology and Hemotherapy in Curitiba were submitted to ELISA testing for the IgA antitransglutaminase antibody. Positive samples received IgA antiendomysium antibody test through indirect immunofluorescence using human umbilical cord as substrate. Subsequently, patients who were positive on both tests underwent small bowel (distal duodenum) biopsy. RESULTS: Six subjects, four males and two females, tested positive for the two serum markers. Five of the six were submitted to intestinal biopsy (one declined the procedure). Biopsy results revealed changes in the distal duodenum mucosa (three classified as Marsh IIIb lesions and two as Marsh II lesions). Most donors diagnosed having celiac disease presented multiple symptoms (gastrointestinal tract complaints). One donor reported having a family history of celiac disease (in a niece). CONCLUSION: Among apparently healthy blood donors, the prevalence of biopsy-confirmed celiac disease was approximately 1:417, similar to that seen in European countries.
Authors: U Volta; S Bellentani; F B Bianchi; G Brandi; L De Franceschi; L Miglioli; A Granito; F Balli; C Tiribelli Journal: Dig Dis Sci Date: 2001-07 Impact factor: 3.199
Authors: J C Gomez; G S Selvaggio; M Viola; B Pizarro; G la Motta; S de Barrio; R Castelletto; R Echeverría; E Sugai; H Vazquez; E Mauriño; J C Bai Journal: Am J Gastroenterol Date: 2001-09 Impact factor: 10.864
Authors: Horacio Vázquez; María de la Paz Temprano; Emilia Sugai; Stella M Scacchi; Cecilia Souza; Daniel Cisterna; Edgardo Smecuol; María Laura Moreno; Gabriela Longarini; Roberto Mazure; María A Bartellini; Elena F Verdú; Andrea González; Eduardo Mauriño; Julio Bai Journal: Can J Gastroenterol Hepatol Date: 2015-07-24
Authors: Lorete Maria da Silva Kotze; Ana Paula Brambila Rodrigues; Luiz Roberto Kotze; Renato Mitsunori Nisihara Journal: World J Gastroenterol Date: 2009-09-21 Impact factor: 5.742
Authors: Lucas Malta Almeida; Luiz Claudio Castro; Rosa Harumi Uenishi; Fernanda Coutinho de Almeida; Patricia Maria Fritsch; Lenora Gandolfi; Riccardo Pratesi; Yanna Karla de Medeiros Nóbrega Journal: World J Gastroenterol Date: 2013-03-28 Impact factor: 5.742
Authors: Marília Lage Alencar; Carmen Lucia Ortiz-Agostinho; Lêda Nishitokukado; Adérson O M C Damião; Clarice P Abrantes-Lemos; André Zonetti de Arruda Leite; Thales de Brito; Dalton de Alencar Fischer Chamone; Maria Elizabeth Rossi da Silva; Daniel Giannella-Neto; Aytan Miranda Sipahi Journal: Clinics (Sao Paulo) Date: 2012-09 Impact factor: 2.365
Authors: Shirley Ramos da Rosa Utiyama; João Luis Coelho Ribas; Renato Mitsunori Nisihara; Lorete Maria da Silva Kotze; Iara José de Messias-Reason Journal: N Am J Med Sci Date: 2010-03
Authors: Mauro W Bonatto; Luiz Kotze; Marcia Orlandoski; Ricardo Tsuchyia; Carlos A de Carvalho; Doryane Lima; Gustavo Kurachi; Ivan R B Orso; Lorete Kotze Journal: Endosc Int Open Date: 2016-06-29
Authors: Lucas Malta Almeida; Lenora Gandolfi; Riccardo Pratesi; Rosa Harumi Uenishi; Fernanda Coutinho de Almeida; Nicole Selleski; Yanna Karla de Medeiros Nóbrega Journal: Autoimmune Dis Date: 2016-11-30