AIMS/HYPOTHESIS: Risk estimates for stroke in patients with diabetes vary. We sought to obtain reliable risk estimates for stroke and the association with diabetes, comorbidity and lifestyle in a large cohort of type 2 diabetic patients in the UK. MATERIALS AND METHODS: Using the General Practice Research Database, we identified all patients who had type 2 diabetes and were aged 35 to 89 years on 1 January 1992. We also identified five comparison subjects without diabetes and of the same age and sex. Hazard ratios (HRs) for stroke between January 1992 and October 1999 were calculated, and the association with age, sex, body mass index, smoking, hypertension, atrial fibrillation and duration of diabetes was investigated. RESULTS: The absolute rate of stroke was 11.91 per 1,000 person-years (95% CI 11.41-12.43) in people with diabetes (n = 41,799) and 5.55 per 1,000 person-years (95% CI 5.40-5.70) in the comparison group (n = 202,733). The age-adjusted HR for stroke in type 2 diabetic compared with non-diabetic subjects was 2.19 (95% CI 2.09-2.32) overall, 2.08 (95% CI 1.94-2.24) in men and 2.32 (95% CI 2.16-2.49) in women. The increase in risk attributable to diabetes was highest among young women (HR 8.18; 95% CI 4.31-15.51) and decreased with age. No investigated comorbidity or lifestyle characteristic emerged as a major contributor to risk of stroke. CONCLUSIONS/ INTERPRETATION: This study provides risk estimates for stroke for an unselected population from UK general practice. Patients with type 2 diabetes were at an increased risk of stroke, which decreased with age and was higher in women. Additional risk factors for stroke in type 2 diabetic patients included duration of diabetes, smoking, obesity, atrial fibrillation and hypertension.
AIMS/HYPOTHESIS: Risk estimates for stroke in patients with diabetes vary. We sought to obtain reliable risk estimates for stroke and the association with diabetes, comorbidity and lifestyle in a large cohort of type 2 diabeticpatients in the UK. MATERIALS AND METHODS: Using the General Practice Research Database, we identified all patients who had type 2 diabetes and were aged 35 to 89 years on 1 January 1992. We also identified five comparison subjects without diabetes and of the same age and sex. Hazard ratios (HRs) for stroke between January 1992 and October 1999 were calculated, and the association with age, sex, body mass index, smoking, hypertension, atrial fibrillation and duration of diabetes was investigated. RESULTS: The absolute rate of stroke was 11.91 per 1,000 person-years (95% CI 11.41-12.43) in people with diabetes (n = 41,799) and 5.55 per 1,000 person-years (95% CI 5.40-5.70) in the comparison group (n = 202,733). The age-adjusted HR for stroke in type 2 diabetic compared with non-diabetic subjects was 2.19 (95% CI 2.09-2.32) overall, 2.08 (95% CI 1.94-2.24) in men and 2.32 (95% CI 2.16-2.49) in women. The increase in risk attributable to diabetes was highest among young women (HR 8.18; 95% CI 4.31-15.51) and decreased with age. No investigated comorbidity or lifestyle characteristic emerged as a major contributor to risk of stroke. CONCLUSIONS/ INTERPRETATION: This study provides risk estimates for stroke for an unselected population from UK general practice. Patients with type 2 diabetes were at an increased risk of stroke, which decreased with age and was higher in women. Additional risk factors for stroke in type 2 diabeticpatients included duration of diabetes, smoking, obesity, atrial fibrillation and hypertension.
Authors: S S Soedamah-Muthu; J H Fuller; H E Mulnier; V S Raleigh; R A Lawrenson; H M Colhoun Journal: Diabetologia Date: 2006-01-24 Impact factor: 10.122
Authors: R G Gibbs; J C Todd; C Irvine; R Lawrenson; R Newson; R M Greenhalgh; A H Davies Journal: Eur J Vasc Endovasc Surg Date: 1998-07 Impact factor: 7.069
Authors: Tobias Kurth; J Michael Gaziano; Klaus Berger; Carlos S Kase; Kathryn M Rexrode; Nancy R Cook; Julie E Buring; JoAnn E Manson Journal: Arch Intern Med Date: 2002 Dec 9-23
Authors: P M Rothwell; A J Coull; M F Giles; S C Howard; L E Silver; L M Bull; S A Gutnikov; P Edwards; D Mant; C M Sackley; A Farmer; P A G Sandercock; M S Dennis; C P Warlow; J M Bamford; P Anslow Journal: Lancet Date: 2004-06-12 Impact factor: 79.321
Authors: John L Kitzmiller; Jennifer M Block; Florence M Brown; Patrick M Catalano; Deborah L Conway; Donald R Coustan; Erica P Gunderson; William H Herman; Lisa D Hoffman; Maribeth Inturrisi; Lois B Jovanovic; Siri I Kjos; Robert H Knopp; Martin N Montoro; Edward S Ogata; Pathmaja Paramsothy; Diane M Reader; Barak M Rosenn; Alyce M Thomas; M Sue Kirkman Journal: Diabetes Care Date: 2008-05 Impact factor: 19.112
Authors: Sherita Hill Golden; Arleen Brown; Jane A Cauley; Marshall H Chin; Tiffany L Gary-Webb; Catherine Kim; Julie Ann Sosa; Anne E Sumner; Blair Anton Journal: J Clin Endocrinol Metab Date: 2012-06-22 Impact factor: 5.958
Authors: Alexandra Kautzky-Willer; Raimund Weitgasser; Peter Fasching; Fritz Hoppichler; Monika Lechleitner Journal: Wien Klin Wochenschr Date: 2012-12 Impact factor: 1.704
Authors: K Eeg-Olofsson; J Cederholm; P M Nilsson; B Zethelius; L Nunez; S Gudbjörnsdóttir; B Eliasson Journal: Diabetologia Date: 2008-11-05 Impact factor: 10.122
Authors: Jane C Khoury; Dawn Kleindorfer; Kathleen Alwell; Charles J Moomaw; Daniel Woo; Opeolu Adeoye; Matthew L Flaherty; Pooja Khatri; Simona Ferioli; Joseph P Broderick; Brett M Kissela Journal: Stroke Date: 2013-04-25 Impact factor: 7.914
Authors: H E Mulnier; H E Seaman; V S Raleigh; S S Soedamah-Muthu; H M Colhoun; R A Lawrenson; C S de Vries Journal: Diabetologia Date: 2008-06-26 Impact factor: 10.122
Authors: Martin C Gulliford; Judith Charlton; Mark Ashworth; Anthony G Rudd; Andre Michael Toschke Journal: PLoS One Date: 2009-09-24 Impact factor: 3.240