Literature DB >> 17072315

Diversity of microRNAs in human and chimpanzee brain.

Eugene Berezikov1, Fritz Thuemmler, Linda W van Laake, Ivanela Kondova, Ronald Bontrop, Edwin Cuppen, Ronald H A Plasterk.   

Abstract

We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.

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Year:  2006        PMID： 17072315     DOI： 10.1038/ng1914

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  228 in total

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