INTRODUCTION: The first embryonic part of the nasal cavity is the primary nasal duct, beginning with the olfactory placode and ending with the oronasal membrane. Aim of this study was to investigate the cellular processes (apoptosis, proliferation) being responsible for development and opening of the primary nasal duct. MATERIAL AND METHODS: In this study developmental processes in at least three regions of the primary nasal duct (opening, middle, end) were examined by sectioning 38 rat fetuses on day 13.5 after conception. Apoptotic cells were detected by active caspase-3 antibodies and proliferating cells were examined by Ki-67 antibodies. RESULTS: Multiple apoptotic events were diagnosed on the basis and proliferative cells on the top of this duct. CONCLUSION: Apoptosis and proliferation play an important role in the process of opening the bottom of the primary nasal duct and for development of the nasal septum, philtrum as well as the primary palate. Mesenchymal proliferation seems to play a minor role in the process of opening the primary nasal duct.
INTRODUCTION: The first embryonic part of the nasal cavity is the primary nasal duct, beginning with the olfactory placode and ending with the oronasal membrane. Aim of this study was to investigate the cellular processes (apoptosis, proliferation) being responsible for development and opening of the primary nasal duct. MATERIAL AND METHODS: In this study developmental processes in at least three regions of the primary nasal duct (opening, middle, end) were examined by sectioning 38 rat fetuses on day 13.5 after conception. Apoptotic cells were detected by active caspase-3 antibodies and proliferating cells were examined by Ki-67 antibodies. RESULTS: Multiple apoptotic events were diagnosed on the basis and proliferative cells on the top of this duct. CONCLUSION: Apoptosis and proliferation play an important role in the process of opening the bottom of the primary nasal duct and for development of the nasal septum, philtrum as well as the primary palate. Mesenchymal proliferation seems to play a minor role in the process of opening the primary nasal duct.
Authors: Teodor Świdziński; Kamila Linkowska-Świdzińska; Hanna Czerniejewska-Wolska; Bożena Wiskirska-Woźnica; Maciej Owecki; Maria Danuta Głowacka; Anna Frankowska; Katarzyna Łącka; Mariusz Glapiński; Zofia Maciejewska-Szaniec; Piotr Świdziński Journal: Biomed Res Int Date: 2016-08-30 Impact factor: 3.411