BACKGROUND: The purpose of the present study was to prospectively measure quality of life (QOL) before and after pulmonary resection for non-small cell lung cancer (NSCLC) and to determine which clinical perioperative variables predicted QOL. METHODS: Thirty-seven patients undergoing a curative resection for early-stage NSCLC were administered the Functional Assessment of Cancer Therapy-Lung (FACT-L) questionnaire serially. This was used to calculate a Trial Outcome Index (TOI), a measure of QOL. RESULTS: Perioperative variables associated with worse postoperative TOI included the presence of preoperative dyspnea (coefficient -7.89, 95% confidence interval -12.4 to -3.31, P = .01) and exposure to adjuvant chemotherapy (-14.7, -20.0 to -9.46, P = .001). CONCLUSIONS: Preoperative dyspnea and postoperative chemotherapy are associated with worse postoperative QOL among patients with resected, early-stage NSCLC. As adjuvant and neoadjuvant therapy protocols become more prevalent for these patients, QOL issues may assume greater importance.
BACKGROUND: The purpose of the present study was to prospectively measure quality of life (QOL) before and after pulmonary resection for non-small cell lung cancer (NSCLC) and to determine which clinical perioperative variables predicted QOL. METHODS: Thirty-seven patients undergoing a curative resection for early-stage NSCLC were administered the Functional Assessment of Cancer Therapy-Lung (FACT-L) questionnaire serially. This was used to calculate a Trial Outcome Index (TOI), a measure of QOL. RESULTS: Perioperative variables associated with worse postoperative TOI included the presence of preoperative dyspnea (coefficient -7.89, 95% confidence interval -12.4 to -3.31, P = .01) and exposure to adjuvant chemotherapy (-14.7, -20.0 to -9.46, P = .001). CONCLUSIONS: Preoperative dyspnea and postoperative chemotherapy are associated with worse postoperative QOL among patients with resected, early-stage NSCLC. As adjuvant and neoadjuvant therapy protocols become more prevalent for these patients, QOL issues may assume greater importance.
Authors: Joshua Bauml; Corey J Langer; Tracey Evans; Sheila N Garland; Krupali Desai; Jun J Mao Journal: Support Care Cancer Date: 2014-04-09 Impact factor: 3.603
Authors: Lee W Jones; Neil D Eves; William E Kraus; Anil Potti; Jeffrey Crawford; James A Blumenthal; Bercedis L Peterson; Pamela S Douglas Journal: BMC Cancer Date: 2010-04-21 Impact factor: 4.430
Authors: Virginia Sun; Jae Y Kim; Dan J Raz; Walter Chang; Loretta Erhunmwunsee; Carolina Uranga; Anne Marie Ireland; Karen Reckamp; Brian Tiep; Jennifer Hayter; Michael Lew; Betty Ferrell; Ruth McCorkle Journal: J Cancer Educ Date: 2018-06 Impact factor: 2.037
Authors: Marko Popovic; Nicholas Lao; Liang Zeng; Liying Zhang; David Cella; Jennifer L Beaumont; Ronald Chow; Nicholas Chiu; Leonard Chiu; Henry Lam; Michael Poon; Edward Chow Journal: Support Care Cancer Date: 2013-03-22 Impact factor: 3.603