OBJECTIVE: To compare the cost implications of treatment of persistent fracture non-unions before and after application of recombinant human bone morphogenetic protein-7 (BMP-7). METHOD: Of 25 fracture non-unions, 9 were treated using BMP-7 alone and 16 using BMP-7 and bone grafting. These patients were prospectively followed up, and the costs incurred were analysed. RESULTS: The mean number of procedures per fracture performed before application of BMP-7 was 4.16, versus 1.2 thereafter. Mean hospital stay and cost of treatment per fracture before receiving BMP-7 were 26.84 days and pound 13,844.68, versus 7.8 days and pound 7338.4 thereafter. The overall cost of treatment of persistent fracture non-unions with BMP-7 was 47.0% less than that of the numerous previous unsuccessful treatments (p=0.001). CONCLUSIONS: Treating fracture non-unions is costly, but this could be reduced by early BMP-7 administration when a complex or persistent fracture non-union is present or anticipated.
OBJECTIVE: To compare the cost implications of treatment of persistent fracture non-unions before and after application of recombinant humanbone morphogenetic protein-7 (BMP-7). METHOD: Of 25 fracture non-unions, 9 were treated using BMP-7 alone and 16 using BMP-7 and bone grafting. These patients were prospectively followed up, and the costs incurred were analysed. RESULTS: The mean number of procedures per fracture performed before application of BMP-7 was 4.16, versus 1.2 thereafter. Mean hospital stay and cost of treatment per fracture before receiving BMP-7 were 26.84 days and pound 13,844.68, versus 7.8 days and pound 7338.4 thereafter. The overall cost of treatment of persistent fracture non-unions with BMP-7 was 47.0% less than that of the numerous previous unsuccessful treatments (p=0.001). CONCLUSIONS: Treating fracture non-unions is costly, but this could be reduced by early BMP-7 administration when a complex or persistent fracture non-union is present or anticipated.
Authors: Kimberly R Garrison; Ian Shemilt; Simon Donell; Jonathan J Ryder; Miranda Mugford; Ian Harvey; Fujian Song; Volker Alt Journal: Cochrane Database Syst Rev Date: 2010-06-16
Authors: Christian von Rüden; Mario Morgenstern; Jan Friederichs; Peter Augat; Simon Hackl; Alexander Woltmann; Volker Bühren; Christian Hierholzer Journal: Int Orthop Date: 2016-08-13 Impact factor: 3.075
Authors: Peter V Giannoudis; Nikolaos K Kanakaris; Rozalia Dimitriou; Ian Gill; Vinod Kolimarala; Richard J Montgomery Journal: Clin Orthop Relat Res Date: 2009-04-24 Impact factor: 4.176