| Literature DB >> 17070524 |
Yousra Abdel-Mottaleb1, Elke Clynen, Amir Jalali, Frank Bosmans, Hossein Vatanpour, Liliane Schoofs, Jan Tytgat.
Abstract
The very first member of K(+) channels toxins from the venom of the Iranian scorpion Odonthobuthus doriae (OdK1) was purified, sequenced and characterized physiologically. OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as alpha-KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K(+) channels (vertebrate Kv1.1-Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183+/-3 nM but did not affect any of the other channels.Entities:
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Year: 2006 PMID： 17070524 DOI： 10.1016/j.febslet.2006.10.029
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124