| Literature DB >> 17070508 |
Hyunkeun Song1, Dae Young Hur, Kyung-Eun Kim, Hyunjeong Park, Taesung Kim, Chul-Woo Kim, Saic Bang, Dae-Ho Cho.
Abstract
TGF-beta is known to play a major role for the reduced NKG2D expression seen in cancer patients. However, the mechanisms for reduced TGF-beta-induced down-regulation of NKG2D are unclear. In this study, we observed that IL-2/IL-18 increased the NKG2D expression in the TGF-beta treated NK cell line in a dose-dependent manner. Incubation with the JNK inhibitor SP600125 inhibited the NKG2D expression induced by IL-2/IL-18 in the TGF-beta treated human NK cell line. Moreover, the NK cytotoxicity assay showed that the reduced NK cytotoxicity by TGF-beta was recovered by IL-2/IL-18 treatment. The results indicate that IL-2/IL-18 strongly prevented the TGF-beta-induced NKG2D down-regulation in NK cells via the JNK pathway. Taken together, the protected expression of NKG2D by IL-2/IL-18 provides insight into the mechanism of NKG2D regulation and it also supplied useful information for creating a novel therapeutic approach to treat TGF-beta-secreting cancer cells.Entities:
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Year: 2006 PMID： 17070508 DOI： 10.1016/j.cellimm.2006.09.002
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868