Energy consumption for the formation of hemoglobin A1c: a reappraisal and implication on the poor-control diabetes mellitus patients.

Diabetes mellitus (DM) is a frequent disorder affecting individuals of all ages. Glycohemoglobin has a key role in the assessment of glycemic control in diabetic patients. Several studies have clearly shown that improved glycemic control is strongly associated with decreased development and/or progression of diabetic complications. The chemical reaction of glycosylation in formation of hemoglobin A(1c) (HbA(1c)) has been described for decades. Here, the author performed a reappraisal on the bonding energy based on quantum chemical analysis. The author calculated the bonding energy of the reaction and found that the reaction is a type of "energy-consuming reaction." In addition, the author gives further implication of the findings on the poor-control DM patients. The author hereby proposed that the nature of energy-consuming reaction in formation of hemoglobin A(1c) (HbA(1c)) is a main underlying for the energy loosing in poorly controlled DM patients. Gathering of the energy from the nearby cellular compartment during formation of HbA(1c) might be an important pathological process.