Literature DB >> 1706906

Inhibition by calcitonin gene-related peptide of agonist-induced bronchoconstriction in various mammals including man.

A Cadieux1, C Lanoue.   

Abstract

The effect of calcitonin gene-related peptide (CGRP) on the smooth muscle of mammalian airways has been investigated in vitro. CGRP itself lacked contractile activity but reduced responses evoked by bronchoconstrictor agents via a post-junctional action. The inhibitory effect of CGRP was concentration-related and greatest in distal airways. The results suggest that CGRP may contribute to regulating muscular tone in the tracheobronchial tree.

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Year:  1990        PMID: 1706906     DOI: 10.1007/978-3-0348-7379-6_26

Source DB:  PubMed          Journal:  Agents Actions Suppl        ISSN: 0379-0363


  1 in total

1.  Immunocytochemical survey of the neuroepithelial endocrine system in the respiratory tract of the Tokyo salamander, Hynobius nebulosus tokyoensis TAgo.

Authors:  T Gomi; Y Kikuchi; D Adriaensen; J P Timmermans; M H De Groodt-Lasseel; A Kimura; H Naruse; Y Ishikawa; K Kishi; D W Scheuermann
Journal:  Histochemistry       Date:  1994-12
  1 in total

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