Literature DB >> 17068762

Autoantigen arrays for multiplex analysis of antibody isotypes.

Kareem L Graham1, Maria Vaysberg, Annie Kuo, Paul J Utz.   

Abstract

We describe here a microarray-based method for multiplexed, antigen-specific assessment of immunoglobulin (Ig) subclasses. We used 1152-feature arrays composed of 140 antigens or antigen fragments to detect isotype-specific mAb, to quantitatively monitor changes in isotype mAb concentration, and to profile antigen-specific antibody isotype production in a murine model of autoimmunity. This platform can be easily adapted to a variety of applications, and has the potential to elucidate mechanisms that govern development and evolution of antibody responses in in vivo and in vitro systems.

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Year:  2006        PMID： 17068762     DOI： 10.1002/pmic.200600345

Source DB:  PubMed          Journal:  Proteomics        ISSN： 1615-9853            Impact factor:   3.984


  7 in total

Review 1.  The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases.

Authors:  Nicole H Kattah; Michael G Kattah; Paul J Utz
Journal:  Immunol Rev       Date:  2010-01       Impact factor: 12.988

2.  IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice.

Authors:  Donna L Thibault; Alvina D Chu; Kareem L Graham; Imelda Balboni; Lowen Y Lee; Cassidy Kohlmoos; Angela Landrigan; John P Higgins; Robert Tibshirani; Paul J Utz
Journal:  J Clin Invest       Date:  2008-04       Impact factor: 14.808

3.  Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies.

Authors:  Elizabeth M Bradshaw; Sally C Kent; Vinay Tripuraneni; Tihamer Orban; Hidde L Ploegh; David A Hafler; J Christopher Love
Journal:  Clin Immunol       Date:  2008-10       Impact factor: 3.969

4.  Treatment with a toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice.

Authors:  Kareem L Graham; Lowen Y Lee; John P Higgins; Lawrence Steinman; Paul J Utz; Peggy P Ho
Journal:  Autoimmunity       Date:  2010-03       Impact factor: 2.815

Review 5.  Development and deployment of antigen arrays for investigation of B-cell fine specificity in autoimmune disease.

Authors:  Jeremy Sokolove; Tamsin M Lindstrom; William H Robinson
Journal:  Front Biosci (Elite Ed)       Date:  2012-01-01

6.  Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus.

Authors:  Donna L Thibault; Kareem L Graham; Lowen Y Lee; Imelda Balboni; Paul J Hertzog; Paul J Utz
Journal:  Arthritis Res Ther       Date:  2009-07-22       Impact factor: 5.156

Review 7.  Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus.

Authors:  Honglin Zhu; Hui Luo; Mei Yan; Xiaoxia Zuo; Quan-Zhen Li
Journal:  Genomics Proteomics Bioinformatics       Date:  2015-09-28       Impact factor: 7.691
  7 in total

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