Literature DB >> 17068089

Recovering metabolic pathways via optimization.

John E Beasley1, Francisco J Planes.   

Abstract

A metabolic pathway is a coherent set of enzyme catalysed biochemical reactions by which a living organism transforms an initial (source) compound into a final (target) compound. Some of the different metabolic pathways adopted within organisms have been experimentally determined. In this paper, we show that a number of experimentally determined metabolic pathways can be recovered by a mathematical optimization model.

Mesh:

Year:  2006        PMID: 17068089     DOI: 10.1093/bioinformatics/btl554

Source DB:  PubMed          Journal:  Bioinformatics        ISSN: 1367-4803            Impact factor:   6.937


  5 in total

1.  A critical view of metabolic network adaptations.

Authors:  Balázs Papp; Bas Teusink; Richard A Notebaart
Journal:  HFSP J       Date:  2008-12-03

Review 2.  The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli.

Authors:  Adam M Feist; Bernhard Ø Palsson
Journal:  Nat Biotechnol       Date:  2008-06       Impact factor: 54.908

3.  A strategy to calculate the patterns of nutrient consumption by microorganisms applying a two-level optimisation principle to reconstructed metabolic networks.

Authors:  Miguel Ponce de León; Héctor Cancela; Luis Acerenza
Journal:  J Biol Phys       Date:  2008-05-14       Impact factor: 1.365

4.  Integrating gene and protein expression data with genome-scale metabolic networks to infer functional pathways.

Authors:  Jon Pey; Kaspar Valgepea; Angel Rubio; John E Beasley; Francisco J Planes
Journal:  BMC Syst Biol       Date:  2013-12-08

Review 5.  Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia.

Authors:  Tunahan Cakir; Selma Alsan; Hale Saybaşili; Ata Akin; Kutlu O Ulgen
Journal:  Theor Biol Med Model       Date:  2007-12-10       Impact factor: 2.432

  5 in total

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