OBJECTIVE: To determine the clinical and long-term implications of mood polarity at illness onset. METHODS: During a 10-year follow-up prospective study, systematic clinical and outcome data were collected from 300 bipolar I and II patients. The sample was split into 2 groups according to the polarity of the onset episode (depressive onset [DO] vs manic/hypomanic onset [MO]). Clinical features and social functioning were compared between the 2 groups of patients. RESULTS: In our sample, 67% of the patients experienced a depressive onset. Depressive onset patients were more chronic than MO patients, with a higher number of total episodes and a longer duration of illness. Depressive onset patients experienced a higher number of depressive episodes than MO patients, who in turn had more manic episodes. Depressive onset patients made more suicide attempts, had a later illness onset, were less often hospitalized, and were less likely to develop psychotic symptoms. Depressive onset was more prevalent among bipolar II patients. Bipolar I patients with DO had more axis II comorbidity and were more susceptible to have a history of psychotic symptoms than bipolar II patients with DO. CONCLUSION: The polarity at onset is a good predictor of the polarity of subsequent episodes over time. A depressive onset is twice as frequent as MO and carries more chronicity and cyclicity.
OBJECTIVE: To determine the clinical and long-term implications of mood polarity at illness onset. METHODS: During a 10-year follow-up prospective study, systematic clinical and outcome data were collected from 300 bipolar I and II patients. The sample was split into 2 groups according to the polarity of the onset episode (depressive onset [DO] vs manic/hypomanic onset [MO]). Clinical features and social functioning were compared between the 2 groups of patients. RESULTS: In our sample, 67% of the patients experienced a depressive onset. Depressive onsetpatients were more chronic than MO patients, with a higher number of total episodes and a longer duration of illness. Depressive onsetpatients experienced a higher number of depressive episodes than MO patients, who in turn had more manic episodes. Depressive onsetpatients made more suicide attempts, had a later illness onset, were less often hospitalized, and were less likely to develop psychotic symptoms. Depressive onset was more prevalent among bipolar IIpatients. Bipolar Ipatients with DO had more axis II comorbidity and were more susceptible to have a history of psychotic symptoms than bipolar IIpatients with DO. CONCLUSION: The polarity at onset is a good predictor of the polarity of subsequent episodes over time. A depressive onset is twice as frequent as MO and carries more chronicity and cyclicity.
Authors: José M Goikolea; Danai Dima; Ramón Landín-Romero; Imma Torres; Giuseppe DelVecchio; Marc Valentí; Benedikt L Amann; Caterina Mar Bonnín; Peter J McKenna; Edith Pomarol-Clotet; Sophia Frangou; Eduard Vieta Journal: Schizophr Bull Date: 2019-03-07 Impact factor: 9.306
Authors: Sadia R Chaudhury; Michael F Grunebaum; Hanga C Galfalvy; Ainsley K Burke; Leo Sher; Ramin V Parsey; Benjamin Everett; J John Mann; Maria A Oquendo Journal: J Affect Disord Date: 2007-04-16 Impact factor: 4.839