Literature DB >> 17067586

Analysis of the hemochromatosis mutations C282Y and H63D in infertile men.

Borut Peterlin1, Tanja Kunej, Helena Hruskovicová, Polonca Ferk, Ksenija Gersak, Branko Zorn.   

Abstract

The aim of this study was to find out whether C282Y and H63D mutations in the hemochromatosis (HFE) gene are associated with male infertility and whether the prevalence of the HFE mutations is higher in a group of 262 infertile men in comparison to 200 fertile men. Because the C282Y and H63D HFE gene distributions in infertile men were not significantly different from fertile controls, our data suggest that the C282Y and H63D HFE gene mutations are not risk factors for male infertility and are not associated with clinical manifestations of male infertility.

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Year:  2006        PMID: 17067586     DOI: 10.1016/j.fertnstert.2006.05.034

Source DB:  PubMed          Journal:  Fertil Steril        ISSN: 0015-0282            Impact factor:   7.329


  3 in total

Review 1.  Genetic causes of spermatogenic failure.

Authors:  Annelien Massart; Willy Lissens; Herman Tournaye; Katrien Stouffs
Journal:  Asian J Androl       Date:  2011-12-05       Impact factor: 3.285

2.  An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population.

Authors:  Xiao-Ying Yu; Bin-Bin Wang; Zhong-Cheng Xin; Tao Liu; Ke Ma; Jian Jiang; Xiang Fang; Li-Hua Yu; Yi-Feng Peng; Xu Ma
Journal:  Asian J Androl       Date:  2012-04-16       Impact factor: 3.285

3.  Hereditary haemochromatosis gene (HFE) H63D mutation shows an association with abnormal sperm motility.

Authors:  Aysen Gunel-Ozcan; M Murad Basar; Ucler Kisa; Handan C Ankarali
Journal:  Mol Biol Rep       Date:  2008-10-10       Impact factor: 2.316

  3 in total

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