BACKGROUND: Pesticide sprayers in mango orchards of Malihabad, Lucknow (India) are generally exposed to organophosphate (OP) and pyrethroid pesticides. We determined the pesticide exposure levels along with their biochemical and clinical effects in 31 sprayers, compared with 18 controls. METHODS: Assay of acetyl and butyrylcholinesterases (AChE, BChE respectively) as an indirect measurement of OP exposure and levels of malondialdehyde (MDA) and glutathione (GSH) were estimated in blood samples to determine their impact on redox potential. Organochlorines were estimated by GLC-ECD. RESULTS: Significantly inhibited AChE, BChE activities and higher MDA level were found among sprayers compared to controls (p<0.05). Mean of total organochlorines were surprisingly higher (97.65+/-13.38 ppb) in sprayers than in those of controls (20.42+/-3.56 ppb) (p<0.05). Respiratory morbidity (32.4%), ocular problems (8.8%), gastrointestinal (17.6%) and skin problems (23.5%) were found in sprayers. There was significant correlation between AChE and GSH (r=0.29, p<0.05) and AChE with MDA (r=-0.34, p<0.05). CONCLUSION: Results indicated the significantly enhanced lipid peroxidation in sprayers correlated with cholinesterases inhibition. A small sample size limits the significance of this study. However, it paves the way for a larger Indian study with extended practical significance.
BACKGROUND: Pesticide sprayers in mango orchards of Malihabad, Lucknow (India) are generally exposed to organophosphate (OP) and pyrethroid pesticides. We determined the pesticide exposure levels along with their biochemical and clinical effects in 31 sprayers, compared with 18 controls. METHODS: Assay of acetyl and butyrylcholinesterases (AChE, BChE respectively) as an indirect measurement of OP exposure and levels of malondialdehyde (MDA) and glutathione (GSH) were estimated in blood samples to determine their impact on redox potential. Organochlorines were estimated by GLC-ECD. RESULTS: Significantly inhibited AChE, BChE activities and higher MDA level were found among sprayers compared to controls (p<0.05). Mean of total organochlorines were surprisingly higher (97.65+/-13.38 ppb) in sprayers than in those of controls (20.42+/-3.56 ppb) (p<0.05). Respiratory morbidity (32.4%), ocular problems (8.8%), gastrointestinal (17.6%) and skin problems (23.5%) were found in sprayers. There was significant correlation between AChE and GSH (r=0.29, p<0.05) and AChE with MDA (r=-0.34, p<0.05). CONCLUSION: Results indicated the significantly enhanced lipid peroxidation in sprayers correlated with cholinesterases inhibition. A small sample size limits the significance of this study. However, it paves the way for a larger Indian study with extended practical significance.
Authors: Graciela Eugenia Bianco; Eva Suarez; Lauro Cazon; Teresita Beatriz de la Puente; Marcelo Rafael Benitez Ahrendts; Julio César De Luca Journal: Environ Sci Pollut Res Int Date: 2017-07-21 Impact factor: 4.223
Authors: Tatiana Vieira Souza Chaves; Muhammad Torequl Islam; Manoel Odoríco de Moraes; Marcus Vinícius Oliveira Barros de Alencar; Débora Cássia Vieira Gomes; Rodrigo Mendes de Carvalho; Sharbel Weider Maluf; Fabrício Pires de Moura do Amaral; Márcia Fernanda Correia Jardim Paz; Gilberto Santos Cerqueira; Hercília Maria Lins Rolim; João Marcelo de Castro E Sousa; Ana Amélia de Carvalho Melo-Cavalcante; Maria Elisabete Amaral de Moraes Journal: Environ Sci Pollut Res Int Date: 2017-05-16 Impact factor: 4.223
Authors: Manoj Kumar Pathak; Mohammad Fareed; Anup Kumar Srivastava; Balram Singh Pangtey; Vipin Bihari; Mohammed Kuddus; C Kesavachandran Journal: Environ Sci Pollut Res Int Date: 2013-05-01 Impact factor: 4.223