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Literature DB >> 17067308

The fundamental contribution of Robert A. Good to the discovery of the crucial role of thymus in mammalian immunity.

Abstract

Robert Alan Good was a pioneer in the field of immunodeficiency diseases. He and his colleagues defined the cellular basis and functional consequences of many of the inherited immunodeficiency diseases. His was one of the groups that discovered the pivotal role of the thymus in the immune system development and defined the separate development of the thymus-dependent and bursa-dependent lymphoid cell lineages and their responsibilities in cell-mediated and humoral immunity.

Entities: Disease Species

Mesh：

Year: 2006 PMID： 17067308 PMCID： PMC1819567 DOI： 10.1111/j.1365-2567.2006.02484.x

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

35 in total

1. Clinicopathologic conference; refractory anemia, agammaglobulinemia, and mediastinal tumor.

Authors: A T LAMBIE; B A BURROWS; S C SOMMERS
Journal: Am J Clin Pathol Date: 1957-04 Impact factor: 2.493

2. Acquired hypogammaglobulinemia in an adult; report of a case, with clinical and experimental studies.

Authors: C M MARTIN; R S GORDON; N B MCCULLOUGH
Journal: N Engl J Med Date: 1956-03-08 Impact factor: 91.245

3. Studies on agammaglobulinemia. II. Failure of plasma cell formation in the bone marrow and lymph nodes of patients with agammaglobulinemia.

Authors: R A GOOD
Journal: J Lab Clin Med Date: 1955-08

4. Agammaglobulinemia.

Authors: C A JANEWAY; L APT; D GITLIN
Journal: Trans Assoc Am Physicians Date: 1953

5. Relationship of the bursa of Fabricius to immunologic responsiveness and homograft immunity in the chicken.

Authors: B W PAPERMASTER; D I FRIEDMAN; R A GOOD
Journal: Proc Soc Exp Biol Med Date: 1962-05

6. Implantation of a foetal thymus, restoring immunological competence in a patient with thymic aplasia (Digeorge's syndrome).

Authors: C S August; F S Rosen; R M Filler; C A Janeway; B Markowski; H E Kay
Journal: Lancet Date: 1968-12-07 Impact factor: 79.321

The fundamental contribution of Robert A. Good to the discovery of the crucial role of thymus in mammalian immunity.

1. Clinicopathologic conference; refractory anemia, agammaglobulinemia, and mediastinal tumor.

2. Acquired hypogammaglobulinemia in an adult; report of a case, with clinical and experimental studies.

3. Studies on agammaglobulinemia. II. Failure of plasma cell formation in the bone marrow and lymph nodes of patients with agammaglobulinemia.

4. Agammaglobulinemia.

5. Relationship of the bursa of Fabricius to immunologic responsiveness and homograft immunity in the chicken.

6. Implantation of a foetal thymus, restoring immunological competence in a patient with thymic aplasia (Digeorge's syndrome).

7. The role of the thymus in antibody production; an experimental study of the immune response in thymectomized rabbits.

8. Thymus-dependent areas in the lymphoid organs of neonatally thymectomized mice.

9. Morphological and functional studies of fetal thymus transplants in mice.

10. The functions of the thymus system and the bursa system in the chicken.

1. Sir Frank Macfarlane Burnet and the clonal selection theory of antibody formation.