Literature DB >> 17067171

Cytotoxic cycloartane triterpene saponins from Actaea asiatica.

Jingchun Gao1, Feng Huang, Jinchao Zhang, Guoyuan Zhu, Mengsu Yang, Peigen Xiao.   

Abstract

Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-beta-D-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-beta-O-D-xyloside (5), and 25-anhydrocimigenol-beta-O-D-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1-3, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.

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Year:  2006        PMID: 17067171     DOI: 10.1021/np060113h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  7 in total

1.  Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis.

Authors:  Yin Nian; Ni-Hong Lu; Xiao-Ling Liu; Da-Shan Li; Lin Zhou; Ming-Hua Qiu
Journal:  RSC Adv       Date:  2018-02-19       Impact factor: 4.036

2.  Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita.

Authors:  Abdul Rahim; Yohei Saito; Katsunori Miyake; Masuo Goto; Chin-Ho Chen; Gemini Alam; Susan Morris-Natschke; Kuo-Hsiung Lee; Kyoko Nakagawa-Goto
Journal:  J Nat Prod       Date:  2018-07-16       Impact factor: 4.050

Review 3.  Anticancer Chemodiversity of Ranunculaceae Medicinal Plants: Molecular Mechanisms and Functions.

Authors:  Da-Cheng Hao; Chun-Nian He; Jie Shen; Pei-Gen Xiao
Journal:  Curr Genomics       Date:  2017-02       Impact factor: 2.236

4.  In Silico Analyses and Cytotoxicity Study of Asiaticoside and Asiatic Acid from Malaysian Plant as Potential mTOR Inhibitors.

Authors:  Ninie Nadia Zulkipli; Rahimah Zakaria; Idris Long; Siti Fadilah Abdullah; Erma Fatiha Muhammad; Habibah A Wahab; Teguh Haryo Sasongko
Journal:  Molecules       Date:  2020-09-02       Impact factor: 4.411

5.  Study of the cytotoxicity of asiaticoside on rats and tumour cells.

Authors:  Fatma J Al-Saeedi
Journal:  BMC Cancer       Date:  2014-03-25       Impact factor: 4.430

6.  New anti-angiogenic leading structure discovered in the fruit of Cimicifuga yunnanensis.

Authors:  Yin Nian; Jing Yang; Tong-Yang Liu; Ying Luo; Ji-Hong Zhang; Ming-Hua Qiu
Journal:  Sci Rep       Date:  2015-03-12       Impact factor: 4.379

7.  Six New 9,19-Cycloartane Triterpenoids from Cimicifuga foetida L.

Authors:  Guo-Lei Zhu; Di-Fan Zhu; Luo-Sheng Wan; Xing-Rong Peng; Ni-Man Bao; Zhi-Run Zhang; Lin Zhou; Ming-Hua Qiu
Journal:  Nat Prod Bioprospect       Date:  2016-05-20
  7 in total

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