| Literature DB >> 17067155 |
Shujun Zhang1, Ming Zhao, Liming Bai, Toshiaki Hasegawa, Jinlan Wang, Liyan Wang, Hongyan Xue, Qigang Deng, Fenglan Xing, Yuhua Bai, Jun-ichi Sakai, Jiao Bai, Rei Koyanagi, Yoshinori Tsukumo, Takao Kataoka, Kazuo Nagai, Katutoshi Hirose, Masayoshi Ando.
Abstract
Two new guaianolides, named chinensiolides D (5) and E (6), were isolated from Ixeris chinensis Nakai, and their structures were determined to be 10alpha-hydroxy-3-oxoguaia-11(13)-eno-12,6alpha-lactone (5) and 10alpha-hydroxy-3beta-O-[2,6-di(p-hydroxyphenylacetyl)-beta-glucopylanosyl]guaia-4(15),11(13)-dieno-12,6alpha-lactone (6). The first isolation of (11S)-10alpha-hydroxy-3-oxoguaia-4-eno-12,6alpha-lactone (4) from natural sources and its characterization are also reported. Chinenciolide E (6) showed significant growth inhibitory activity toward VA-13 malignant lung tumor cells (IC50 = 0.72 microM).Entities:
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Year: 2006 PMID： 17067155 DOI： 10.1021/np068015j
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050