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Literature DB >> 1706557

Acidic fibroblast growth factor (aFGF) is present in the fluid of brain tumour pseudocysts.

Abstract

Fluid samples from brain tumour pseudocysts were examined for the presence of Fibroblast Growth Factor (FGF). Fluids were collected from 6 patients with differentiated low grade gliomas (group A), 3 anaplastic gliomas (group B) and 3 metastases (group C). For FGF assays pooled fluids from group A, B, and C were subjected to affinity chromatography on a Heparin-Sepharose column. Each pool contained endothelial cell mitogenic activity which eluted in the 1.2 M NaCl fraction and to a lesser degree in the 0.6 M fraction of Heparin-Sepharose high affinity chromatography. Mitogenic activity in the 1.2 M NaCl fraction of Heparin-Sepharose chromatography suggests the presence of acidic FGF (aFGF).

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Year: 1990 PMID： 1706557 DOI： 10.1007/bf01405785

Source DB: PubMed Journal: Acta Neurochir (Wien) ISSN： 0001-6268 Impact factor: 2.216

42 in total

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Authors: R R Lobb; J W Fett
Journal: Biochemistry Date: 1984-12-18 Impact factor: 3.162

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Journal: J Neurosurg Date: 1985-10 Impact factor: 5.115

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Authors: A Baird; N Ling
Journal: Biochem Biophys Res Commun Date: 1987-01-30 Impact factor: 3.575

3. Platelet-derived growth factor (PDGF) in neoplastic and non-neoplastic cystic lesions of the central nervous system and in the cerebrospinal fluid.

Authors: M Nistér; P Enblad; G Bäckström; T Söderman; L Persson; C H Heldin; B Westermark
Journal: Br J Cancer Date: 1994-05 Impact factor: 7.640

3 in total