| Literature DB >> 17064898 |
Dafydd R Owen1, Peter G Dodd, Simon Gayton, Ben S Greener, Gareth W Harbottle, Simon J Mantell, Graham N Maw, Simon A Osborne, Huw Rees, Tracy J Ringer, Margarita Rodriguez-Lens, Graham F Smith.
Abstract
A series of novel mGluR1 antagonists have been prepared. Incorporation of fragments derived from weak lead matter into a library led to enhanced potency in a new chemical series. A chemistry driven second library iteration, covering a greatly enhanced area of chemical space, maintained good potency and introduced metabolic stability.Entities:
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Year: 2006 PMID： 17064898 DOI： 10.1016/j.bmcl.2006.10.015
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823