| Literature DB >> 17064767 |
Yen-Chen Chen1, Shao-Yuan Chen, Pey-Shen Ho, Chia-Huei Lin, Ya-Yuan Cheng, Jehng-Kang Wang, Huey-Kang Sytwu.
Abstract
Tumor cells with different origins have different threshold to apoptosis. Hematopoietic (Jurkat, NCI-H929) cells and non-hematopoietic (A549, MCF-7) cells were received hyperbaric oxygen (HBO(2)) treatment from 2.5 to 3.5 atmosphere absolute (ATA) of 100% oxygen for 6h, and a significant percentage of apoptosis were shown only in hematopoietic Jurkat and NCI-H929 cells by either Annexin V or TUNEL assay. Oxidative stress was illustrated higher in HBO(2)-treated hematopoietic cells by superoxide fluorochrome detectors. HBO(2) treatment leads to caspase-3, caspase-7 activation and further cleavage of PARP within cells. Furthermore, the increased phosphorylation of p38 MAPK was demonstrated in both Jurkat and NCI-H929 cells.Entities:
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Year: 2006 PMID： 17064767 DOI： 10.1016/j.leukres.2006.09.016
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156