Literature DB >> 17064691

Circulating gastrin is increased in hemochromatosis.

Kelly A Smith1, Suzana Kovac, Gregory J Anderson, Arthur Shulkes, Graham S Baldwin.   

Abstract

Gastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively. Since non-amidated gastrins require ferric ions for biological activity in vitro, this study investigated the connection between iron status and gastrin by measurement of circulating gastrin concentrations in mice and humans with hemochromatosis. Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe(-/-) mice, and in the sera of humans with HFE-related hemochromatosis. The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis.

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Year:  2006        PMID： 17064691      PMCID： PMC1780041          DOI： 10.1016/j.febslet.2006.10.021

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  30 in total

Review 1.  The orchestration of body iron intake: how and where do enterocytes receive their cues?

Authors:  David M Frazer; Gregory J Anderson
Journal:  Blood Cells Mol Dis       Date:  2003 May-Jun       Impact factor: 3.039

2.  Short term infusion of glycine-extended gastrin(17) stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa.

Authors:  A Aly; A Shulkes; G S Baldwin
Journal:  Int J Cancer       Date:  2001-11-01       Impact factor: 7.396

3.  Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice.

Authors:  T J Koh; J R Goldenring; S Ito; H Mashimo; A S Kopin; A Varro; G J Dockray; T C Wang
Journal:  Gastroenterology       Date:  1997-09       Impact factor: 22.682

4.  Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

Authors:  Kim R Bridle; David M Frazer; Sarah J Wilkins; Jeanette L Dixon; David M Purdie; Darrell H G Crawford; V Nathan Subramaniam; Lawrie W Powell; Gregory J Anderson; Grant A Ramm
Journal:  Lancet       Date:  2003-02-22       Impact factor: 79.321

Review 5.  Gastrins, cholecystokinins and gastrointestinal cancer.

Authors:  Ahmad Aly; Arthur Shulkes; Graham S Baldwin
Journal:  Biochim Biophys Acta       Date:  2004-07-06

6.  Role of gastric acid in food iron absorption.

Authors:  B S Skikne; S R Lynch; J D Cook
Journal:  Gastroenterology       Date:  1981-12       Impact factor: 22.682

7.  Divergent roles for ferric ions in the biological activity of amidated and non-amidated gastrins.

Authors:  J Pannequin; J-P Tantiongco; S Kovac; A Shulkes; G S Baldwin
Journal:  J Endocrinol       Date:  2004-05       Impact factor: 4.286

8.  Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin.

Authors:  Julie Pannequin; Kevin J Barnham; Frederic Hollande; Arthur Shulkes; Raymond S Norton; Graham S Baldwin
Journal:  J Biol Chem       Date:  2002-09-20       Impact factor: 5.157

9.  A novel effect of bismuth ions: selective inhibition of the biological activity of glycine-extended gastrin.

Authors:  Julie Pannequin; Suzana Kovac; John-Paul Tantiongco; Raymond S Norton; Arthur Shulkes; Kevin J Barnham; Graham S Baldwin
Journal:  J Biol Chem       Date:  2003-10-06       Impact factor: 5.157

10.  Gastrin and colorectal cancer: a prospective study.

Authors:  C M Thorburn; G D Friedman; C J Dickinson; J H Vogelman; N Orentreich; J Parsonnet
Journal:  Gastroenterology       Date:  1998-08       Impact factor: 22.682
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  6 in total

1.  Definition of the residues required for the interaction between glycine-extended gastrin and transferrin in vitro.

Authors:  Suzana Kovac; Audrey Ferrand; Jean-Pierre Estève; Anne B Mason; Graham S Baldwin
Journal:  FEBS J       Date:  2009-07-31       Impact factor: 5.542

2.  Stimulation of proliferation in the colorectal mucosa by gastrin precursors is blocked by desferrioxamine.

Authors:  Audrey Ferrand; Shamilah Lachal; Gianni Bramante; Suzana Kovac; Arthur Shulkes; Graham S Baldwin
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2010-04-15       Impact factor: 4.052

3.  Ferric ions inhibit proteolytic processing of progastrin.

Authors:  Gianni Bramante; Oneel Patel; Arthur Shulkes; Graham S Baldwin
Journal:  Biochem Biophys Res Commun       Date:  2010-12-30       Impact factor: 3.575

Review 4.  Gastrins, iron homeostasis and colorectal cancer.

Authors:  Suzana Kovac; Gregory J Anderson; Graham S Baldwin
Journal:  Biochim Biophys Acta       Date:  2011-02-12

5.  Interrelationships between circulating gastrin and iron status in mice and humans.

Authors:  Suzana Kovac; Kelly Smith; Gregory J Anderson; John R Burgess; Arthur Shulkes; Graham S Baldwin
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2008-08-28       Impact factor: 4.052

6.  Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Authors:  Antonio Agudo; Catalina Bonet; Núria Sala; Xavier Muñoz; Núria Aranda; Ana Fonseca-Nunes; Françoise Clavel-Chapelon; Marie Christine Boutron-Ruault; Paolo Vineis; Salvatore Panico; Domenico Palli; Rosario Tumino; Sara Grioni; J Ramón Quirós; Esther Molina; Carmen Navarro; Aurelio Barricarte; Saioa Chamosa; Naomi E Allen; Kay-Tee Khaw; H Bas Bueno-de-Mesquita; Peter D Siersema; Mattijs E Numans; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Rudof Kaaks; Federico Canzian; Heiner Boeing; Karina Meidtner; Mattias Johansson; Malin Sund; Jonas Manjer; Kim Overvad; Anne Tjonneland; Eiliv Lund; Elisabete Weiderpass; Mazda Jenab; Veronika Fedirko; G Johan A Offerhaus; Elio Riboli; Carlos A González; Paula Jakszyn
Journal:  Carcinogenesis       Date:  2013-02-06       Impact factor: 4.944
  6 in total

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